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View Structure Prediction Details

Protein: rgef-1
Organism: Caenorhabditis elegans
Length: 654 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rgef-1.

Description E-value Query
Range
Subject
Range
gi|45501258 - gi|45501258|gb|AAH67298.1| RASGRP1 protein [Homo sapiens]
365.0 [0..12] [618..58]

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Predicted Domain #1
Region A:
Residues: [1-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKVEEDQH QELLTEDQLV ARCVECFDVD EEDEVEDIEF VDALFLSHQW LSDSLSLITH  60
   61 FVNFYQETRN VEQREAVCRA VSFWIEKFPM HFDAQPQVCA QVVRLKTIAE DINENIRNGL 120
  121 DVSALPSFAW LRAVSVRNPL AKQTAFSLSF VQASPSDIST SLSHIDYRVL SRISITELKQ 180
  181 YVKDGHLRSC PMLERSISVF NNLSNWVQCM ILNKTTPKER AEILVKFVHV AKHLRKINNF 240
  241 NTLMSVVGGI THSSVARLAK TYAVLSNDIK KELTQLTNLL SAQHNFCEYR KALGACNKKF 300
  301 RIPIIGVHLK DLVAINCSGA NFEKTKCISS DKLVKLSKLL SNFLVFNQKG HNLPEMNMDL 360
  361 INTLKVSLDI RYNDDDIYEL SLRREPKTFM NFEPSRGLVF AEWASGVTVA PDNATVSKHI 420
  421 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.522879
Match: 2ii0A
Description: No description for 2ii0A was found.

Predicted Domain #2
Region A:
Residues: [421-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAMVDAVFKH YDHDRDGFIS QEEFQLIAGN FPFIDAFVNI DVDMDGQISK DELKTYFMAA  60
   61 NKNTKDLRRG FKHNFHETTF LTPTTCNHCN KLLWGILRQG FKCKDCGLAV HSCCKSNAVA 120
  121 ECRRKSSSNL TRAAEWFASP RGSMRSRIIN TCKRSSRPRT VSAVVTSPTT EKPTCSTKLS 180
  181 PPKLKDIRPQ SESTEYYNSG STPDEEIGLV SLACEEVFED DDLADISSAS YRTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
binding 2.15139804299723 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009
transcription regulator activity 0.0455432286632499 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle