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View Structure Prediction Details

Protein: ero-1
Organism: Caenorhabditis elegans
Length: 478 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ero-1.

Description E-value Query
Range
Subject
Range
gi|73952532 - gi|73952532|ref|XP_546074.2| PREDICTED: similar to endoplasmic reticulum oxidoreductin 1-Lbeta [Cani...
632.0 [0..10] [459..309]

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Predicted Domain #1
Region A:
Residues: [1-478]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREPLLQLIV LSLIIIVVNT QFESGRLCFC KGFEAVEPCD CSKPQTIDKL NNHRIYEKVQ  60
   61 KLLKKDFFRF YKVNMDKTCP FWADDRQCGT NQCGIAFCDD EVPAGLRRRN AVNMEAAAVK 120
  121 EEEDDDAEKC ADAGNNIDPM DRTLHDDEKR QLDAMDHHDD GLEDKFCEIE DDESDGMHYV 180
  181 DLSKNPERYT GYAGKSPQRV WKSIYEENCF KPDPKFDKNF LTNPSNFGMC LEKRVFYRLI 240
  241 SGLHSAITIS IAAYNYKPPP PSLGQFGSQM GTWFRNTEMF AGRFGTKWSW EGPQRLRNVY 300
  301 FIYLLELRAL LKAAPYLQNE LFYTGNDVED AETRKAVEDL LEEIRAYPNH FDESEMFTGV 360
  361 ESHARALREE FRSHFVNISR IMDCVECDKC RLWGKVQTHG MGTALKILFS DLPHSHYKQD 420
  421 SSKFQLTRNE VVALLQSFGR YSSSILEVDN FREDMYPGES VMNTAADGPP RKSNKIDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 1rq1A
Description: Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on sulfur group of donors 3.04541306149882 bayes_pls_golite062009
thiol oxidase activity 1.56067935587779 bayes_pls_golite062009
binding 1.51315006963036 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 1.31287436426921 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.25764823859811 bayes_pls_golite062009
unfolded protein binding 1.21113889423637 bayes_pls_golite062009
catalytic activity 1.09506175640279 bayes_pls_golite062009
protein binding 0.524855475418758 bayes_pls_golite062009
disulfide oxidoreductase activity 0.384901602591813 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle