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View Structure Prediction Details

Protein: nhr-14
Organism: Caenorhabditis elegans
Length: 434 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-14.

Description E-value Query
Range
Subject
Range
gi|5702091 - gi|5702091|gb|AAD47137.1|AF061181_1 green fluorescent protein-estrogen receptor alpha fusion [Mammal...
303.0 [0..8] [396..444]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFLISTSLS ESTSTSADFC VVCGDKAIGK HYGAVACNGC KGFFRRSVWQ NLQYTCRFNK  60
   61 QCNIDKDHRN ACRYCRFQKC LADGMKPEAI QNERDRIGST K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [102-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRKRSGANSE NNSDSEGTPS PKIEVMGNSV SRKLIEMLLD IEHRLASNQS MNALLRDESE  60
   61 MKNSRQRAVN YLIGWTNMLH PLPEVPLADK VLLLKKFSSA FTLLGTLQRS MALPHFVLPN 120
  121 DQVLSISASH PPELFEALTR IIDELLTPLR RLRTDHAEFS CLKALLLLNP DVVGISNNTR 180
  181 ERIREARDAL LKTLFAYMSN TQNSIDASLR VSSLLMIIPS LISVSSSIME FPALSDLFGL 240
  241 GDVIKRDTIS PKIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.221849
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
receptor activity 2.62895787183554 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
steroid hormone receptor activity 2.30195937604451 bayes_pls_golite062009
transcription repressor activity 2.20686235000733 bayes_pls_golite062009
molecular transducer activity 2.04709877069886 bayes_pls_golite062009
signal transducer activity 2.04709877069886 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
nuclear hormone receptor binding 1.60419100774741 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
retinoic acid receptor binding 1.28118886948947 bayes_pls_golite062009
transcription coactivator activity 1.23834725221597 bayes_pls_golite062009
retinoid X receptor binding 0.99801784942981 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
hormone receptor binding 0.74373733735458 bayes_pls_golite062009
promoter binding 0.58091332905515 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
receptor binding 0.418843034756825 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
lipid binding 0.164046651023989 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [356-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPPLEMKPMM PKIAQPPVTS APTVPTNIMM NKDLISQIMN NPQLFPLLPM PQTASPPMSF  60
   61 MGQSYNRNSD VIFSQCPSK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle