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View Structure Prediction Details

Protein: hif-1
Organism: Caenorhabditis elegans
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hif-1.

Description E-value Query
Range
Subject
Range
CE18671 - WBGene00001851 locus:hif-1 status:Partially_confirmed TR:O45486 protein_id:CAA19520.1
228.0 [0..13] [503..333]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSEYLDR KYTESPMGAF TTRHTCDMRI TFVSDKFNYI LKSELKTLMG TSFYELVHPA  60
   61 DMMIVSKSMK ELFAKGHIRT PYYRLIAAND TLAWIQTEAT TITHTTKGQK GQYVICVHYV 120
  121 LGIQGAEESL VVCTDSM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.0
Match: 1p97A
Description: NMR structure of the C-terminal PAS domain of HIF2a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.438711522487185 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAGMQVDIKK EVDDTRDYIG RQPEIVECVD FTPLIEPEDP FDTVIEPVVG GEEPVKQADM  60
   61 GARKNSYDDV LQWLFRDQPS SPPPARYRSA DRFRTTEPSN FGSALASPDF MDSSSRTSRP 120
  121 KTSYGRRAQS QGSRTTGSSS TSASATLPHS ANYSPLAEGI SQCGLNSPPS IKSGQVVYGD 180
  181 ARSMGRSCDP SDSSRRFSAL SPSDTLNVSS TRGINPVIGS NDVFSTMPFA DSIA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [372-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAERIDSSPT LTSGEPILCD DLQWEEPDLS CLAPFVDTYD MMQMDEGLPP ELQALYDLPD  60
   61 FTPAVPQAPA ARPVHIDRSP PAKRMHQSGP SDLDFMYTQH YQPFQQDETY WQGQQQQNEQ 120
  121 QPSSYSPFPM LS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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