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View Structure Prediction Details

Protein: nhr-66
Organism: Caenorhabditis elegans
Length: 526 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-66.

Description E-value Query
Range
Subject
Range
gi|7507499 - gi|7507499|pir||T33028 hypothetical protein T09A12.4 - Caenorhabditis elegans
294.0 [0..1] [526..185]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVIRLLDFM TASTDVFAAM DMSQKQSSPP GIFKIAKNEP SSSSNSQPGT PAMGDRRAVP  60
   61 ACAICGTDST GIHFGVDACA ACSAFFRRTV VLNKDYSCNK GGKCTVVKDG SAGQKCRACR 120
  121 FRKCISSGMD KNSVQHRRDA IGKYSAGVKR ELSPDAEFEP SAKVSTVSEP STSSGPSGGF 180
  181 NQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [184-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSSPAGIPRV PSTLRTTQAS TCMNSACGQK SVLHELICRQ NFLTEQRQLF YAGCLGDWFR  60
   61 KPSSIENQTL SELTDFSSCM FHLWKIEPRL AADFMNRNRY LDPLPIVEKL KIYRNFVIMR 120
  121 QSVEEPYLTW RHGGLEKRWF VMPNNTYIDF NNIAKYFENG ALKDLKLDYE TTTNLFLPSF 180
  181 THAMDTIGEK MKKNNITETE LTILLGLVLL DPGIYGIHES TRKFLKRIRD QLIHDVYMYY 240
  241 EDEMSHLYDP EIRMADIFML VAAIKIHSIK TSENMHMLRV FDLIPADACF NQMLDVESVN 300
  301 VSPDGQKDSE AEQGPSPVSV PEAARGSYQD DDMPPVLEKN CDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.09691
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15996699473685 bayes_pls_golite062009
transcription regulator activity 0.46162010671465 bayes_pls_golite062009
protein binding 0.33427459029264 bayes_pls_golite062009
nucleic acid binding 0.15459949087509 bayes_pls_golite062009
DNA binding 0.14395376162921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle