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View Structure Prediction Details

Protein: apx-1
Organism: Caenorhabditis elegans
Length: 515 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for apx-1.

Description E-value Query
Range
Subject
Range
gi|68440657 - gi|68440657|ref|XP_688293.1| PREDICTED: similar to secreted protein SST3 [Danio rerio]
346.0 [0..34] [504..2083]

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Predicted Domain #1
Region A:
Residues: [1-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNFSSLLTT IFLCIISSAT GSGTIELLIS SPQTVLVEPT VCANFECAAP DDLSLARKVQ  60
   61 RRVPLRFGTG QYHGEARERI DLHLKIIEPT SNEILALQHH RPAADTEWNS DAPIVIETSR 120
  121 GFNVTVQLRN LCSSNYHGKR CNRYCIANAK LHWECSTHGV RRCSAGWSGE DCSNPICAGG 180
  181 CSNRGRCVAP NQCSCADGFN GTRCEQCLPR AGCVNGDCVN ETPNTCKCRD GFIGDRCDID 240
  241 IKICSLEKPC ANGGICSIDS SSSTGYKCHC PFEFVGSQCK TPLSKVRCSA EHVCKNGGAC 300
  301 ISMDDTNIQC KCRRGFSGKF CEIGNHGDCS AMRCSAGETC QISGDFAICV ENDELLLTTN 360
  361 KPAETTKSVE KWREPRKTAN DEQASDELQL RLIAAICVLF SVCVIGLALV SFFFYMHSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ErbB-2 class receptor binding 2.49988032150831 bayes_pls_golite062009
receptor binding 2.31571280660349 bayes_pls_golite062009
ErbB-3 class receptor binding 2.14752073450101 bayes_pls_golite062009
binding 2.14092582858845 bayes_pls_golite062009
protein binding 1.87564165872234 bayes_pls_golite062009
signal transducer activity 1.48171797015526 bayes_pls_golite062009
molecular transducer activity 1.48171797015526 bayes_pls_golite062009
epidermal growth factor receptor binding 1.08974638257724 bayes_pls_golite062009
growth factor activity 0.402016723620225 bayes_pls_golite062009
pattern binding 0.0196006376432096 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [420-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKWKHPSSQQ AGGSTILPTT TSIPMSTTSS GTGSPVYKVC IIDSEHRGNA PGSSSDSEPD  60
   61 HHCPPPHRHS PPPAYSSLVL YKKVPMAADD ESSFRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1jv2B
Description: Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle