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View Structure Prediction Details

Protein: mls-2
Organism: Caenorhabditis elegans
Length: 341 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mls-2.

Description E-value Query
Range
Subject
Range
gi|68437229 - gi|68437229|ref|XP_699549.1| PREDICTED: homeo box C11b [Danio rerio]
138.0 [0..1] [265..40]

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Predicted Domain #1
Region A:
Residues: [1-187]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTSVMNLPI DMTTMSSQER LEKMSQLPKI ELMEEEEEEE MKPSSDNKIK FNISELLEDD  60
   61 RKPTTQSSPS ASSEDSTNEI EQTAFNFNFD PKMNPISALL QLQQTFLNVG NQQNMISPLT 120
  121 MFPFFGLPTA QLMHFKNMSN PDVNIQSDNG EEKDEKSEGK DGETRDSTGG SPLESDAEDD 180
  181 DDIGRGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [188-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEANSSDPS QNRKKKTRTV FSRSQVSQLE MMFECKRYLS SQERSNLAQK LHLTETQVKI  60
   61 WFQNRRNKFK RQAQTDDTNI SLQMHRANVF SIPATTALTS PILTIPTTSA GVNMRNMISS 120
  121 PMDASATAAA RFLFGFGTLQ AQQNLNASAQ AQNM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.09839603329852 bayes_pls_golite062009
DNA binding 3.70287146988839 bayes_pls_golite062009
nucleic acid binding 3.64380968064654 bayes_pls_golite062009
transcription factor activity 3.09799997792958 bayes_pls_golite062009
sequence-specific DNA binding 2.60514736539172 bayes_pls_golite062009
binding 2.38790799849051 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.24140562598253 bayes_pls_golite062009
transcription activator activity 2.19769864782568 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription repressor activity 1.04797217475639 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.83458785143486 bayes_pls_golite062009
chromatin binding 0.806325172844419 bayes_pls_golite062009
transcription factor binding 0.54291661516816 bayes_pls_golite062009
transcription cofactor activity 0.012862302676295 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle