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View Structure Prediction Details

Protein: unc-60
Organism: Caenorhabditis elegans
Length: 212 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-60.

Description E-value Query
Range
Subject
Range
gi|54673670, gi|... - gi|54673670|gb|AAH43148.2| Twinfilin, actin-binding protein, homolog 1 (Drosophila) [Homo sapiens], ...
gi|190690019, gi... - gi|190691391|gb|ACE87470.1| twinfilin, actin-binding protein, homolog 1 (Drosophila) protein [synthe...
183.0 [0..2] [211..38]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGVMVDPD VQTSFQKLSE GRKEYRYIIF KIDENKVIVE AAVTQDQLGI TGDDYDDSSK  60
   61 AAFDKFVEDV KSRTDNLTDC RYAVFDFKFT CSRVGAGTSK MDKIIFLQIC PDGASIKKKM 120
  121 VYASSAAAIK TSLGTGKILQ FQVSDESEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1f7sA
Description: Cofilin (actin depolymerizing factor, ADF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.52071741004022 bayes_pls_golite062009
cytoskeletal protein binding 6.04859625643932 bayes_pls_golite062009
actin filament binding 5.45532510538573 bayes_pls_golite062009
binding 2.84811181543046 bayes_pls_golite062009
protein binding 1.87981807141519 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.3406661967545 bayes_pls_golite062009
phosphatidylserine binding 0.588992286163708 bayes_pls_golite062009
structural constituent of cytoskeleton 0.482954032096802 bayes_pls_golite062009
actin monomer binding 0.224304003054399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [150-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHKELLNNCP DNAPVRRRML YASSVRALKA SLGLESLFQV QASEMSDLDE KSVKSDLMSN  60
   61 QRI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.72
Match: 1m4jA
Description: Adf-H domain of twinfilin isoform-1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle