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View Structure Prediction Details

Protein: lin-1
Organism: Caenorhabditis elegans
Length: 441 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-1.

Description E-value Query
Range
Subject
Range
gi|20270188, gi|... - gi|55661633|emb|CAH70131.1| ets variant gene 3 [Homo sapiens], gi|20270188|ref|NP_005231.1| ets vari...
gi|123992959, gi... - gi|124000497|gb|ABM87757.1| ets variant gene 3 [synthetic construct], gi|123992959|gb|ABM84081.1| et...
180.0 [0..45] [167..16]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNHIDLLKVK KEPPSSSEEA EEEESPKHTI EGILDIRKKE MNVSDLMCTR SSTPPTSSSV  60
   61 DSIITLWQFL LELLQQDQNG DIIEWTRGTD GEFRLIDAEA VARKWGQRKA KPHMNYDKLS 120
  121 RALRYYYEKN IIKKVIGKKF VYRFVTTDAH APPTADFSSN MNMKMCYVKD E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.221849
Match: 1mdmB
Description: ETS-1 transcription factor, residues 331-440
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.20862608643434 bayes_pls_golite062009
binding 2.18911933843505 bayes_pls_golite062009
DNA binding 1.78415975685994 bayes_pls_golite062009
nucleic acid binding 1.64150017312029 bayes_pls_golite062009
transcription factor activity 1.30418360837022 bayes_pls_golite062009
transcription repressor activity 0.55739080981393 bayes_pls_golite062009
transcription activator activity 0.14130464856269 bayes_pls_golite062009
sequence-specific DNA binding 0.13573040816325 bayes_pls_golite062009
protein binding 0.035220363090062 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [172-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDIRHEIPSF MTSLQAPPPP PPPPQNPRGN TDFSALSLLG TDSPTTHSVS TPSPTDSVCS  60
   61 PSSSVASSAT PSTSSPVDES RQCRKRSLSP STTSSTTAPP PPPQPPTKKG MKPNPLNLTA 120
  121 TSNFSLQPSI SSPLLMLQQH HQNSPLFQAQ ISQLYTYAAL AS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #3
Region A:
Residues: [334-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGLYGPQISP HLASQSPFRS PLVTPKNLGL GELGSSGRTP GLGESQVFQF PPVSAFQATN  60
   61 PLLNTFSNLI SPMAPFMMPP SQSSTSFKFP SSTDSLKTPT VPIKMPTL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle