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View Structure Prediction Details

Protein: lin-3
Organism: Caenorhabditis elegans
Length: 423 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-3.

Description E-value Query
Range
Subject
Range
lin-3 - lin-3 growth factor precursor status:Confirmed UniProt:Q03345 protein_id:CAA92997.2
502.0 [0..1] [423..1]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKMLLFCIL LLFMPQFTVS ESCLPSWFRQ ERSAPEQLQS AENAAENSGS VPPDTSRNSL  60
   61 ETNEIGDAPS STSTPETPTE TTISEAGDDE KRTEEVAKEL IEKEAEYEGE YEDEKVDEEV 120
  121 EEALKYNEDA TQDATSTLKP AVRKEIEKLK EAKCKDYCHH NATCHVEVIF REDRVSAVVP 180
  181 SCHCPQGWEG TRCDRHYVQA FYAPING

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
epidermal growth factor receptor binding 4.60166610111644 bayes_pls_golite062009
receptor binding 3.10014156620054 bayes_pls_golite062009
ErbB-2 class receptor binding 2.49988032150831 bayes_pls_golite062009
ErbB-3 class receptor binding 2.42594378586851 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
protein binding 1.97546801934296 bayes_pls_golite062009
growth factor activity 1.86884324063738 bayes_pls_golite062009
signal transducer activity 1.66401431847753 bayes_pls_golite062009
molecular transducer activity 1.66401431847753 bayes_pls_golite062009
transcription factor binding 0.795087651578297 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [208-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYNQSSTSAI PAFAFLIVML IMFITIVVYA YRRMSKRSDD MTYTMSHMCP PEAFNVLKTP  60
   61 NGRHIPVHQI PSCSYTIPTP GTVPPNISST PGSRIPTRQQ AIRNNEQARN NFFSILRSQG 120
  121 TIPSRSINDD DTPKHYKSVP RVEVSAINYS GHIDFSTVSY QSTESEVSKA SVTCPPPAHT 180
  181 VINIELDSAD TNFRSPSRSS GEQGSPATCE PMIRHT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle