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View Structure Prediction Details

Protein: pole-2
Organism: Caenorhabditis elegans
Length: 534 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pole-2.

Description E-value Query
Range
Subject
Range
POLE2 - polymerase (DNA directed), epsilon 2 (p59 subunit)
481.0 [0..7] [513..3]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTTAEENAL RREIVKTFQI HAFELKKEAV KLCVKLFLDH DKETRKKWTN KMIELLKKQT  60
   61 LQSSLISEEL IRDTFRQCKS KGTQDAGKLL NVFDAFSLQP YDFDADLRKM VLRKEKTSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AADSSSFSHA ARQRFFIVKQ RAMRCASLKN FKFTTCEILG SSTKHLQSVV VLGMLTQQKA  60
   61 DCYHIEDLSG SVEVEFKEDT KFHHALFHEH SIAIFEGTFE NSVLTVNEVA MVPVESAEVT 120
  121 RKELSSNENW FGGDDKI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [257-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFRCSDRLRS ALAKQEDTSL VFLSDVFLDD KKVMKAVFKL LQGYKDQPPV AIVFCGNFCS  60
   61 RPRQTDTIDL LDRGFRWLAN QLTPLRKDYE KTQFIFVPGP DDPFVDTVLP RPHLPSLLFK 120
  121 HISPIISCTF ASNPCRIQFA SQEIVVFRSD LIKKTCRHSI NSITVESIPS RYARSVLSQA 180
  181 HLCPLPQHIT PVLPDFSHSL SLHPLPDLLI TADRFETFTE KVVGADTIVS NPGSFSRSNY 240
  241 TFHVYYPCQN RVEASQIPVS ELDDHSNIKN VIIFFFLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 2dxlA
Description: No description for 2dxlA was found.

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 2.11518948144723 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.74872156325503 bayes_pls_golite062009
protein serine/threonine phosphatase activity 1.72108778738758 bayes_pls_golite062009
transferase activity 1.70522125323477 bayes_pls_golite062009
catalytic activity 1.39852585255405 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.23036240099336 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.899406797746366 bayes_pls_golite062009
binding 0.852545739165539 bayes_pls_golite062009
phosphatase activity 0.76188635342041 bayes_pls_golite062009
protein binding 0.306836734324834 bayes_pls_golite062009
hydrolase activity 0.303024521214706 bayes_pls_golite062009
structural molecule activity 0.204234628453541 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle