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View Structure Prediction Details

Protein: ptb-1
Organism: Caenorhabditis elegans
Length: 453 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ptb-1.

Description E-value Query
Range
Subject
Range
gi|480289, gi|397524 - pir||S36629 polypyrimidine tract-binding protein PTB-2 - rat, gi|397524|emb|CAA52653.1| polypyrimidi...
275.0 [0..3] [453..124]

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Predicted Domain #1
Region A:
Residues: [1-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPQVLTSD HPYHQHDVVF RTAVVPAAPV NNNDVVVGAA STGRAAGKSV ANGSVSNFEV  60
   61 GTQQQPNSVL RTIIENMMFP VSLDVLYQLF TRYGKVLRII TFNKNNTFQA LVQMSEANSA 120
  121 QLAKQGLENQ NVYNGCCTLR IDYSKLSTLN VKYNNDKSRD YTNPNLPAGE MTLEQTIAMS 180
  181 IPGLQNLIPA NPYNFAFGAN PATTFLTTQL AASTAAAAAV NDSANAAALA PYLNPLGLTS 240
  241 ANLAPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 1sjrA
Description: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.38904784081546 bayes_pls_golite062009
nucleic acid binding 0.535128751388028 bayes_pls_golite062009
RNA binding 0.423111514770653 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [247-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISSMRFPMIN LTPVILVSNL HEMKVTTDAL FTLFGVYGDV MRVKILYNKK DNALIQYSEP  60
   61 QQAQLALTHL DKVKWHDRLI RVAPSKHTNV QMPKEGQPDA GLTRDYAHST LHRFKKPGSK 120
  121 NYLNIYPPCA TLHLSNIPTS VSEEKLKEMF AEAGFAVKAF KFFPKDHKMA LCQLEDIETA 180
  181 IDALIAMHNH KLAENAHLRV SFSKSGI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.522879
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.38904784081546 bayes_pls_golite062009
nucleic acid binding 0.535128751388028 bayes_pls_golite062009
RNA binding 0.423111514770653 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle