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View Structure Prediction Details

Protein: ptb-1
Organism: Caenorhabditis elegans
Length: 615 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ptb-1.

Description E-value Query
Range
Subject
Range
gi|114674372 - gi|114674372|ref|XP_001172084.1| PREDICTED: polypyrimidine tract-binding protein 1 [Pan troglodytes]
319.0 [0..63] [615..390]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKRGPDDLQ LSLRNGVGGA STTAPGVAAA AYYANVMTAD SEPKKAKLDP TLYSSQFYTP  60
   61 AMHHGLMTAD ASTVAAVTAA ANATTAQLLT GNPITQIQGI QLSTLPQCNS TSAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [115-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSIPVSKVVH VRNIPPDLVD VELMQLCIQY GPVSNYMMLK GKSQAFVEYE EEASAAAFVS  60
   61 GMTAVPIQIR GRTLFAQYST HRELKFDKNK AISDTESVAN GSVSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.09691
Match: 2cq1A
Description: solution structure of RNA binding domain in PTB-like protein L
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [220-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEVGTQQQPN SVLRTIIENM MFPVSLDVLY QLFTRYGKVL RIITFNKNNT FQALVQMSEA  60
   61 NSAQLAKQGL ENQNVYNGCC TLRIDYSKLS TLNVKYNNDK SRDYTNPNLP AGEMTLEQTI 120
  121 AMSIPGLQNL IPANPYNFAF GANPATTFLT TQLAASTAAA AAVNDSANAA ALAPYLNPLG 180
  181 LTSANLAPSI SSMRFPMI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [418-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLTPVILVSN LHEMKVTTDA LFTLFGVYGD VMRVKILYNK KDNALIQYSE PQQAQLALTH  60
   61 LDKVKWHDRL IRVAPSKHTN VQMPKEGQPD AGLTRDYAHS TLHRFKKPGS KNYLNIYPPC 120
  121 ATLHLSNIPT SVSEEKLKEM FAEAGFAVKA FKFFPKDHKM ALCQLEDIET AIDALIAMHN 180
  181 HKLAENAHLR VSFSKSGI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle