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View Structure Prediction Details

Protein: nhr-46
Organism: Caenorhabditis elegans
Length: 395 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-46.

Description E-value Query
Range
Subject
Range
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
234.0 [0..49] [395..206]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSADNHCDI TNESRNRCRA CRLRNCLEGG MNPKHVREER SKIERMPGNT CTVSAANGVS  60
   61 HSSSAASASP EHKFSFSLST IAPSTSTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.09691
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [89-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFSSGSQPAP IESTNSSGSE AEVLDRKLIQ ENQLTLFMVA LEKQTEQLTD DDVKDNDVMG  60
   61 AWSRDITLTF GLQHPQMVIK RLPLKYSCDR IMEAADLYLS WYRSFVFAAD WAMGIPEFRV 120
  121 LPLADQTTLF KQNFMAFGWI TFAYKCFELK QHLTGMPLGN GAYIPYNDED QKKLPERWAQ 180
  181 TYGVVCRKLI DLIVKAMIEL QITEEEYCLI KTISLFQQDC ILSEAGQGIC SRMRDRLLDA 240
  241 LSAHIEKRYP YHTTSQRMTR ALKISLMLPS FSHIGQVEST LITQLTAADL HQLSGVPMEI 300
  301 CTAQTTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.045757
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15996699473685 bayes_pls_golite062009
transcription regulator activity 0.46162010671465 bayes_pls_golite062009
protein binding 0.33427459029264 bayes_pls_golite062009
nucleic acid binding 0.15459949087509 bayes_pls_golite062009
DNA binding 0.14395376162921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle