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View Structure Prediction Details

Protein: nhr-46
Organism: Caenorhabditis elegans
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-46.

Description E-value Query
Range
Subject
Range
gi|76631078 - gi|76631078|ref|XP_887036.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
287.0 [0..24] [572..2]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELFRSPPQT AMFPTTASSS FVSAALHQQQ SSPSSNLPVI PSPTDMITVT STSPIPITTS  60
   61 ASPPNLPMFL SFPSTSTTTS ILMDTVLAAQ KLNQQQNQQA FNFMVVKQEN GETGRNFMTM 120
  121 KQDALQAITN TVSRNSPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVIKGERCVG CGSESAIRVH YGASSCHGCK AFFRRSVFEG RVYMCSADNH CDITNESRNR  60
   61 CRACRLRNCL EGGMNPKHVR EERSKIERMP GNTCTVSAAN GVSHSSSAAS ASPEHKFSFS 120
  121 LST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
binding 0.270879137859077 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [262-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAPSTSTGSF SSGSQPAPIE STNSSGSEAE VLDRKLIQEN QLTLFMVALE KQTEQLTDDD  60
   61 VKDNDVMGAW SRDITLTFGL QHPQMVIKRL PLKYSCDRIM EAADLYLSWY RSFVFAADWA 120
  121 MGIPEFRVLP LADQTTLFKQ NFMAFGWITF AYKCFELKQH LTGMPLGNGA YIPYNDEDQK 180
  181 KLPERWAQTY GVVCRKLIDL IVKAMIELQI TEEEYCLIKT ISLFQQDCIL SEAGQGICSR 240
  241 MRDRLLDALS AHIEKRYPYH TTSQRMTRAL KISLMLPSFS HIGQVESTLI TQLTAADLHQ 300
  301 LSGVPMEICT AQTTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.522879
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15996699473685 bayes_pls_golite062009
transcription regulator activity 0.46162010671465 bayes_pls_golite062009
protein binding 0.33427459029264 bayes_pls_golite062009
nucleic acid binding 0.15459949087509 bayes_pls_golite062009
DNA binding 0.14395376162921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle