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View Structure Prediction Details

Protein: nhr-80
Organism: Caenorhabditis elegans
Length: 486 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-80.

Description E-value Query
Range
Subject
Range
ESR1_FELCA - Estrogen receptor OS=Felis catus GN=ESR1 PE=2 SV=1
283.0 [0..1] [485..174]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEASSSST RCLICSAQAT GFHFEAQSCS ACAAFFRRTV ALTKSFKCIT GRDDCNVHYS  60
   61 MHQICRSCRH KKCLSNGMKP GGVQPKKPNI ETGRAFFTKS GLKRNKKFAN VSPQTADEQK 120
  121 LVVEGVKVPK IEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.44628241003393 bayes_pls_golite062009
DNA binding 1.94519080035201 bayes_pls_golite062009
nucleic acid binding 1.85629109425119 bayes_pls_golite062009
protein binding 1.72653516930292 bayes_pls_golite062009
binding 1.62447538331668 bayes_pls_golite062009
transcription factor activity 1.37728257720121 bayes_pls_golite062009
transcription activator activity 1.10952708883226 bayes_pls_golite062009
sequence-specific DNA binding 0.78199243307321 bayes_pls_golite062009
catalytic activity 0.472235543748473 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.38848912999406 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [134-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEPNSLEDLE QDNEFVIKTP TPRKISSSTS FSASTTTNYS TPGPSPMAPC SAGPDVLTLF  60
   61 IREEMKLGER RRLLFSERAV GTLLGQNKHC PYKKEDIKPL VFHDFRLTIK THIMLVYEWL 120
  121 QTWPELQELD DFDRMSLLRK AVLIHFLLDP SFLSYQIGEP DKLIMQNGGF ISTADHHGVG 180
  181 WEDETDISGE NKRKYYVPIM KQITDEIMPA MEAMKITFEE FVALKALACF QGGFENVSEA 240
  241 KRHLITQQVN RIMTSLHTHY LENSEEKIAE RFGTIVLMLS NIFTAGNDFV QNHREIDIFH 300
  301 IWDLDKLVLQ LLNLDKIMET EARETAEKRA MRNGINVVNN NNDVLLGQAK LEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.96722324965091 bayes_pls_golite062009
DNA binding 3.25939553877631 bayes_pls_golite062009
nucleic acid binding 3.16396885393239 bayes_pls_golite062009
transcription activator activity 2.6892852470567 bayes_pls_golite062009
transcription factor activity 2.56099230851339 bayes_pls_golite062009
binding 2.51356324019445 bayes_pls_golite062009
protein binding 2.49676963514373 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 2.20144353900307 bayes_pls_golite062009
sequence-specific DNA binding 2.1684625121246 bayes_pls_golite062009
signal transducer activity 1.57315744720763 bayes_pls_golite062009
molecular transducer activity 1.57315744720763 bayes_pls_golite062009
receptor activity 1.28597420456904 bayes_pls_golite062009
transcription factor binding 0.78455053961808 bayes_pls_golite062009
steroid hormone receptor activity 0.71366308307673 bayes_pls_golite062009
transcription repressor activity 0.49585672359082 bayes_pls_golite062009
catalytic activity 0.477341996033689 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.36233153809872 bayes_pls_golite062009
retinoic acid receptor activity 0.26050147400703 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle