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View Structure Prediction Details

Protein: lin-3
Organism: Caenorhabditis elegans
Length: 438 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-3.

Description E-value Query
Range
Subject
Range
lin-3 - lin-3 growth factor precursor status:Confirmed UniProt:Q03345 protein_id:CAD27623.1
795.0 [0..1] [438..1]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKMLLFCIL LLFMPQFTVS ESCLPSWFRQ ERSAPEQLQS AENAAENSGS VPPDTSRNSL  60
   61 ETNEIGDAPS STSTPETPTE TTISEAGDDE KRTEEVAKEL IEKEAEYE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEYEDEKVDE EVEEALKYNE DATQDATSTL KPAVRKEIEK LKEAKCKDYC HHNATCHVEV  60
   61 IFREDRVSAV VPSCHCPQGW EGTRCDRHYV QAFYAPINGR YNVRLSTMSS TAQLLVQQS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.996
Match: 1wheA
Description: COAGULATION FACTOR, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
epidermal growth factor receptor binding 4.08248920636506 bayes_pls_golite062009
receptor binding 2.76510818289785 bayes_pls_golite062009
ErbB-2 class receptor binding 1.90147602324004 bayes_pls_golite062009
ErbB-3 class receptor binding 1.85625693531369 bayes_pls_golite062009
signal transducer activity 1.66370136016696 bayes_pls_golite062009
molecular transducer activity 1.66370136016696 bayes_pls_golite062009
binding 1.62855234773036 bayes_pls_golite062009
growth factor activity 1.47902993477961 bayes_pls_golite062009
transcription factor binding 0.568897560911761 bayes_pls_golite062009
protein binding 0.448653666571103 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [228-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSAIPAFAF LIVMLIMFIT IVVYAYRRMS KRSDDMTYTM SHMCPPEAFN VLKTPNGRHI  60
   61 PVHQIPSCSY TIPTPGTVPP NISSTPGSRI PTRQQAIRNN EQARNNFFSI LRSQGTIPSR 120
  121 SINDDDTPKH YKSVPRVEVS AINYSGHIDF STVSYQSTES EVSKASVTCP PPAHTVINIE 180
  181 LDSADTNFRS PSRSSGEQGS PATCEPMIRH T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle