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View Structure Prediction Details

Protein: vab-3
Organism: Caenorhabditis elegans
Length: 455 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vab-3.

Description E-value Query
Range
Subject
Range
gi|2696970 - gi|2696970|dbj|BAA24023.1| PAX6 SS [Cynops pyrrhogaster]
258.0 [0..2] [385..18]

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Predicted Domain #1
Region A:
Residues: [1-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDAGHTGVN QLGGVFVNGR PLPDATRQRI VDLAHKGCRP CDISRLLQVS NGCVSKILCR  60
   61 YYESGTIRPR AIGGSKPRVA TSDVVEKIED YKRDQPSIFA WEIRDKLLAD NICNNETIPS 120
  121 VSSINRVLRN LAAKKEQVTM QTELYDRIRI VDNFPYNSSW YGQWPIPMNG AVGLNPFVPA 180
  181 PLIEPKTEGE FEKDEDQKPP TEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.30103
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [204-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDAAARMRL KRKLQRNRTS FTQVQIESLE KEFERTHYPD VFARERLAQK IQLPEARIQV  60
   61 WFSNRRAKWR REEKMRNKRS SGTMDSSLSN GTPTPTPGSV TGSNMTNPIG SPASTPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [321-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFPSNNSANL PTTNFVPQTS QMYAGLSQPA MDPYSFGIAN GFSMAPYPQV TDFQPHHMFQ  60
   61 GRSPYDFPYP RMPTNGHGFQ QSMSPATTAV GDIPTLSSGM SLPVSAVLNS IDPSLTHSQM 120
  121 HELSDLTQEH YWRPQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle