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View Structure Prediction Details

Protein: efl-2
Organism: Caenorhabditis elegans
Length: 412 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for efl-2.

Description E-value Query
Range
Subject
Range
gi|7510004 - gi|7510004|pir||T31602 hypothetical protein Y48C3A.t - Caenorhabditis elegans
354.0 [0..1] [412..59]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPSSIDLGS IPGGSEQQQH EDGAAAAAGS PKEVFRSQQS LGLITQRFMS LRQRNEVLNL  60
   61 NEVAKELNIS KRRVYDVINV LEGLGYVEKV EKNNIRWIGD NN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1cf7A
Description: Cell cycle transcription factor E2F-4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.04426015975991 bayes_pls_golite062009
binding 1.99063774159045 bayes_pls_golite062009
DNA binding 1.63968725174405 bayes_pls_golite062009
nucleic acid binding 1.51035375793093 bayes_pls_golite062009
transcription factor activity 1.16072080355661 bayes_pls_golite062009
transcription repressor activity 0.55739080981393 bayes_pls_golite062009
sequence-specific DNA binding 0.17466804820317 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [103-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSEEQNALEA RVEMLRQQEK LLELMIRDAQ AIIELHFEDP IERPYNYVSK EDIRKTAEPN  60
   61 TKSIIVKSEL DTSSSFEIQV TDPSTSGSHD MIVRNKNGVK SHALLFTNDP PEYGDEEDED 120
  121 DVKKLSSQKR FETSEALRVT LAEMLTDPTT ISSSPKHIKL EEPEEIDTED LETFAPPEFS 180
  181 ENKWSQKIGG GLAILWAWLA LMPRPQNGNF FSAKF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [318-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKFFPETVAR KTFVLPPSTS ASQSNAPYLP ETPGRGLFFS PFKSLIDPCI LPSFSDDLTS  60
   61 GYINITTPSR ATGAGAGASG QEDEEPVSVM DFFSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle