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View Structure Prediction Details

Protein: CE24124
Organism: Caenorhabditis elegans
Length: 312 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE24124.

Description E-value Query
Range
Subject
Range
gi|116000813 - gi|116000813|emb|CAL50493.1| bifunctional dihydrofolate reductase-thymidylate synthase 2 / DHFR-TS (...
475.0 [0..6] [312..441]

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Predicted Domain #1
Region A:
Residues: [1-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKENIIADA PSDVVKTVQQ QVHLNQDEYK YLKQVEQILR EGTRRDDRTG TGTISIFGMQ  60
   61 SKYCLRNGTI PLLTTKRVYW KGVLEELLWF ISGSTDGKLL MEKNVKIWEK NGDRAFLDNL 120
  121 GFTSREEGDL GPVYGFQWRH FGAKYVDCHT DYSGQGVDQL AEVIRQIKEQ PDSRRIIMSA 180
  181 WNPSDLGQMV LPPCHTMCQF YVDNGELSCQ LYQRSGDMGL GVPFNLASYG LLTHMIAKVC 240
  241 GLKPGTLVHT LGDAHVYSNH VDALKIQLDR EPYAFPKIRF TRDVASIDDF TSDMIALDDY 300
  301 KCHPKIPMDM AV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 130.0
Match: 1hw4A
Description: Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thymidylate synthase activity 6.6988475347328 bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity 6.29181090719132 bayes_pls_golite062009
binding 1.89072001556053 bayes_pls_golite062009
catalytic activity 1.73427871128495 bayes_pls_golite062009
transferase activity 1.72626940963556 bayes_pls_golite062009
methyltransferase activity 0.927096828883487 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.91282507161672 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle