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View Structure Prediction Details

Protein: hsf-1
Organism: Caenorhabditis elegans
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsf-1.

Description E-value Query
Range
Subject
Range
gi|45643032 - gi|45643032|gb|AAS72410.1| heat shock transcription factor 1 [Caenorhabditis elegans]
336.0 [0..1] [671..1]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPTGNQIQQ NQQQQQQLIM RVPKQEVSVS GAARRYVQQA PPNRPPRQNH QNGAIGGKKS  60
   61 SVTIQEVPNN AY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LETLNKSGNN KVDDDKLPVF LIKLWNIVED PNLQSIVHWD DSGASFHISD PYLFGRNVLP  60
   61 HFFKHNNMNS MVRQLNMYGF RKMTPLSQGG LTRTESDQDH LEFSHPCFVQ GRPELLSQIK 120
  121 RKQSARTVED KQVNEQTQQN LEVVMAEMRA MREKAKNMED KMNKLTKENR DMWTQMGSMR 180
  181 QQHARQQQYF KKLLHFLVSV M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.77201910025409 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
DNA binding 3.44642410378325 bayes_pls_golite062009
nucleic acid binding 3.25777282180864 bayes_pls_golite062009
transcription factor activity 2.83460075788873 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
sequence-specific DNA binding 2.08341148210578 bayes_pls_golite062009
transcription activator activity 1.98504395280033 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transcription factor binding 0.63938506997853 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.49916895549368 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [274-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPGLSKRVAK RGVLEIDFCA ANGTAGPNSK RARMNSEEGP YKDVCDLLES LQRETQEPFS  60
   61 RRFTNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [340-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGPLISEVTD EFGNSPVGRG SAQDLFGDTF GAQSSRYSDG GATSSREQSP HPIISQPQSN  60
   61 SAGAHGANEQ KPDDMYMGSG PLTHENIHRG ISALKRDYQG ASPASGGPST SSSAPSGAGA 120
  121 GARMAQKRAA PYKNATRQMA QPQQDYSGGF VNNYSGFMPS DPSMIPYQPS HQYLQPHQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [518-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLMAIEDQHH PTTSTSSTNA DPHQNLYSPT LGLSPSFDRQ LSQELQEYFT GTDTSLESFR  60
   61 DLVSNHNWDD FGNNVPLDDD EEGSEDPLRQ LALENAPETS NYDGAEDLLF DNEQQYPENG 120
  121 FDVPDPNYLP LADEEIFPHS PALRTPSPSD PNLV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle