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View Structure Prediction Details

Protein: tdc-1
Organism: Caenorhabditis elegans
Length: 650 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tdc-1.

Description E-value Query
Range
Subject
Range
tdc-1 - aromatic-L-amino-acid decarboxylase status:Partially_confirmed UniProt:Q95ZS2 protein_id:CAC42319.1
492.0 [0..1] [623..1]

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Predicted Domain #1
Region A:
Residues: [1-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYGLGEALK NLNSYCQERT TRIRNSLSPS RPSMSEATAT GSSSSSRAST TIPSTPNMDV  60
   61 TPTVEDPRQN DNNASGMTRD EFRQYGKETV DYIVDYLENI QKRRVVPAIE PGYLKDLIPS 120
  121 EAPNTPESFE SVMEDFEKLI MPGITHWQHP RFHAYFPAGN SFPSIIADML SDAIGCVGFS 180
  181 WAACPAMTEL ELIMLDWFGK MIGLPAEFLP LTENGKGGGV IQSSASECNF VTLLAARFEV 240
  241 MKELRQRFPF VEEGLLLSKL IAYCSKEAHS SVEKACMIGM VKLRILETDS KFRLRGDTLR 300
  301 NAIQEDRNLG LIPFFVSTTL GTTSCCSFDV LSEIGPICKE NELWLHVDAA YSGSAFICPE 360
  361 FRPLMNGIEY AMSFNTNPNK WLLINFDCST MWVRDRFKLT QALVVDPLYL QHSWMDKSID 420
  421 YRHWGIPLSR RFRSLKLWFV IRMYGIDGLQ KYIREHVRLA KKMETLLRAD AKFEIVNEVI 480
  481 MGLVCFRMKG DDELNQTLLT RLNASGRIHM VPASLGDRFV IRFCVCAENA TDKDIEVAYE 540
  541 IIAQATQHVL HDSVKAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.0
Match: 1js3A
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-aminobutyrate transaminase activity 2.49533238079952 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
5-aminolevulinate synthase activity 1.01853440922526 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.130698724135981 bayes_pls_golite062009
carbon-carbon lyase activity 0.11598778799668 bayes_pls_golite062009
aromatic-L-amino-acid decarboxylase activity 0.10589462882093 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [558-650]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAEEDEEAVA LEEMVADLNI TETPEKCLTR QNSANAAESG QKLERQLSKE EILAQKQHES  60
   61 LAKKRYTPQP LDLALAPDSD PELSPCSPQI LVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle