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View Structure Prediction Details

Protein: nhr-80
Organism: Caenorhabditis elegans
Length: 504 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-80.

Description E-value Query
Range
Subject
Range
gi|76631078 - gi|76631078|ref|XP_887036.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
297.0 [0..1] [466..75]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEGRYLEI RKKTVKSKFR FPASSSSTRC LICSAQATGF HFEAQSCSAC AAFFRRTVAL  60
   61 TKSFKCITGR DDCNVHYSMH QICRSCRHKK CLSNGMKPGG VQPKKPNIET GRAFFTKSGL 120
  121 KRNKKFANVS PQTADEQKLV V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.045757
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.44628241003393 bayes_pls_golite062009
DNA binding 1.94519080035201 bayes_pls_golite062009
nucleic acid binding 1.85629109425119 bayes_pls_golite062009
protein binding 1.72653516930292 bayes_pls_golite062009
binding 1.62447538331668 bayes_pls_golite062009
transcription factor activity 1.37728257720121 bayes_pls_golite062009
transcription activator activity 1.10952708883226 bayes_pls_golite062009
sequence-specific DNA binding 0.78199243307321 bayes_pls_golite062009
catalytic activity 0.472235543748473 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.38848912999406 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [142-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGVKVPKIEV QEPNSLEDLE QDNEFVIKTP TPRKISSSTS FSASTTTNYS TPGPSPMAPC  60
   61 SAGPDVLTLF IREEMKLGER RRLLFSERAV GTLLGQNKHC PYKKEDIKPL VFHDFRLTIK 120
  121 THIMLVYEWL QTWPELQELD DFDRMSLLRK AVLIHFLLDP SFLSYQIGEP DKLIMQNGGF 180
  181 ISTADHHGVG WEDETDISGE NKRKYYVPIM KQITDEIMPA MEAMKITFEE FVALKALACF 240
  241 QGGFENVSEA KRHLITQQVN RIMTSLHTHY LENSEEKIAE RFGTIVLMLS NIFTAGNDFV 300
  301 QNHREIDIFH IWDLDKLVLQ LLNLDKIMET EARETAEKRA MRNGINVVNN NNDVLLGQAK 360
  361 LEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.96722324965091 bayes_pls_golite062009
DNA binding 3.25939553877631 bayes_pls_golite062009
nucleic acid binding 3.16396885393239 bayes_pls_golite062009
transcription activator activity 2.6892852470567 bayes_pls_golite062009
transcription factor activity 2.56099230851339 bayes_pls_golite062009
binding 2.51356324019445 bayes_pls_golite062009
protein binding 2.49676963514373 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 2.20144353900307 bayes_pls_golite062009
sequence-specific DNA binding 2.1684625121246 bayes_pls_golite062009
signal transducer activity 1.57315744720763 bayes_pls_golite062009
molecular transducer activity 1.57315744720763 bayes_pls_golite062009
receptor activity 1.28597420456904 bayes_pls_golite062009
transcription factor binding 0.78455053961808 bayes_pls_golite062009
steroid hormone receptor activity 0.71366308307673 bayes_pls_golite062009
transcription repressor activity 0.49585672359082 bayes_pls_golite062009
catalytic activity 0.477341996033689 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.36233153809872 bayes_pls_golite062009
retinoic acid receptor activity 0.26050147400703 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle