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View Structure Prediction Details

Protein: daf-5
Organism: Caenorhabditis elegans
Length: 627 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-5.

Description E-value Query
Range
Subject
Range
gi|187023096, gi... - gi|39591339|emb|CAE73392.1| Hypothetical protein CBG20832 [Caenorhabditis briggsae], gi|187023096|em...
gi|157752762 - gi|157752762|ref|XP_001680093.1| Hypothetical protein CBG20832 [Caenorhabditis briggsae AF16]
649.0 [0..1] [627..1]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSPIGSSQ QVEPEHRTPD LMDIDPLIAN LKALHEETRS DDDDDGQPST SAKRKDSRAD  60
   61 GIVIHQKKYS DPGRFLWIWL LGVRVPALSI DGEPHLPIEI LDDMLTKKDK KDQMSFQNLL 120
  121 RYKNVYIRMA SPSQFRAVME KSKECENLNI TSLSLMSRSD IERIMGELRL ESMLTLAEHD 180
  181 NWDISDRVHV VHVNFIDYCS EWLESDDLEE DVMQSGTHGY WY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1l8rA
Description: Retinal determination protein Dachshund
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.15084451351262 bayes_pls_golite062009
DNA binding 1.89121395172205 bayes_pls_golite062009
nucleic acid binding 1.85709490142946 bayes_pls_golite062009
transcription factor activity 1.63947569382682 bayes_pls_golite062009
binding 1.25832675558318 bayes_pls_golite062009
transcription repressor activity 0.602655539932971 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [223-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNRRNMRCIE CQHCEGKFTP TDFIMHHHYP IKPSGFVHTG CNSFQWIRLI EVFDKSNENL  60
   61 EAWNKFVLNS HRAGKREYDE AAPHQAPPKR 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.93
Match: 1mr1C
Description: SMAD4-binding domain of oncoprotein Ski
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.83423962165591 bayes_pls_golite062009
binding 1.34661437993129 bayes_pls_golite062009
nucleic acid binding 0.859383583344931 bayes_pls_golite062009
DNA binding 0.736673094382699 bayes_pls_golite062009
protein binding 0.531073393510436 bayes_pls_golite062009
transcription factor activity 0.40038585689413 bayes_pls_golite062009
transcription repressor activity 0.183703906743894 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [313-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAMETPVPVA ADNGWEADEE EEGEEIVDRD ADIEKCKLRN KKKMENLHIA DFLGPSGSKG  60
   61 LK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [375-627]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRNKFEAVII EQLNKMDDAA LEALFLKSPE EYNLWVKESD FTHKVVTQQQ EWKAKMKDPN  60
   61 FKSRASANFD VSKGEFDNMR HFDNASKATR QEIQQLAEQF ANLDRDAKLL TPMEFVLREH 120
  121 ALLKNVSADA IRVLCNRPPL PPLPPPPPPP KPKPAPVQPI SLGNINFVAL AQQLIASGIK 180
  181 LPLPIVTPPV VSTPAPVITP IPAALPISPN SDFLKQQLST AMSSPALLSL YPKLTAGAYE 240
  241 QLAQFIKTTT VKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle