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View Structure Prediction Details

Protein: daf-19
Organism: Caenorhabditis elegans
Length: 780 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-19.

Description E-value Query
Range
Subject
Range
daf-19 - DAF-19 long variant DNA binding transcription factor status:Partially_confirmed UniProt:Q09555 prote...
666.0 [0..1] [780..1]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNEEPVPST SSVLSAAEKN VKIETPSRKR KGLDIDALWR KKFKDVENQK SPEKSEKSEK  60
   61 TIKEEPLETH PSGERKLRSA SKDSKSLSKE THNTISTRSS SSGTPRKKME PEDVKPNIKM 120
  121 LKKSLPVSFQ CSNLNDGTVG DEMEVIQHST DDPNGTREEF DYNQIEYGNA VTPNGTYTLY 180
  181 APDSNYAPYY QYSNNMQSSP QDNAPYLVPA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [211-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQSPVSIDDA DSINLPNNQR ASPATVNWLF ENYEIGEGSL PRCELYDHYK KHCAEHRMDP  60
   61 VNAASFGKLI RSVFHNLKTR RLGTRGNSKY HYYGIRLKDS STLHSMQHPQ PQIIQNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 1dp7P
Description: Class II MHC transcription factor RFX1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.98990675336286 bayes_pls_golite062009
DNA binding 3.4273272886116 bayes_pls_golite062009
nucleic acid binding 3.38054693035398 bayes_pls_golite062009
transcription factor activity 2.80110428028438 bayes_pls_golite062009
binding 2.18911933843505 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.58663416877618 bayes_pls_golite062009
transcription activator activity 0.53294679084865 bayes_pls_golite062009
sequence-specific DNA binding 0.53285802828572 bayes_pls_golite062009
transcription repressor activity 0.513853050429619 bayes_pls_golite062009
protein binding 0.035220363090062 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [328-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTPPMQLPQR DAYADTVNQV AAIKYMDVEI PDKRARKDNS SSSSSCRDSV SPCMDLPAQQ  60
   61 TIQHTPVHSV IPSTQQPAPL HNNNVVSYVV TESDKAAMGK IDLPIVPFPD KDALMATIGF 120
  121 RKLGVGEEEL NSLIDIYEIL CREILALIKN IDFASVEDTW SKFWSGNFGV DRDHISALCT 180
  181 LDQVQDYIIE VDLALYQTIV DTLIPNVLLS ELSTGMTQTC RTFAKNIDVY LRKSLMLANL 240
  241 GEFFVKKKIQ AIKYLQQGLK RYTSLNHLAH ASRGVLMKPE QVQQMYQDY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [617-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRVDINTVHQ QAGWICGCDS VMVHHVNNAF KHNLQRMSAM EVWAEWLESI VDQVLAKYHD  60
   61 KPANVIANVG KQFLLNWSFY TSMIIRDLTL RSAMSFGSFT LIRLLADDYM YYLIESKIAK 120
  121 AGKQQLITVI RADKDWPLTT NPQEYIVVAN DNDEDLDLEK AGLL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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