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View Structure Prediction Details

Protein: kpc-1
Organism: Caenorhabditis elegans
Length: 692 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for kpc-1.

Description E-value Query
Range
Subject
Range
gi|2264334 - gi|2264334|gb|AAB63525.1| celfur protein
535.0 [0..1] [692..1]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNISWYRHC SVRLQLVTLA LFLLLGSASL GSAHIDEEFE DDVTTTISSI ASPMRRTYTN  60
   61 EWAVRIAGGK VEEANRLANK YGYTNLGPII PGDEYYLFRD DRKKSRSSRK TRSLSANQLQ 120
  121 HEEDVMWMEQ QVAKRRVKRG YRRIRRHTDD NDIFEEDDDG TQISKSRNRK HPDPNDPLWT 180
  181 DMWYLNRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.30103
Match: 2p4eP
Description: No description for 2p4eP was found.

Predicted Domain #2
Region A:
Residues: [189-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHHSDSTTRM DHNVKEAWDL GYTGKGVVVT ILDDGLERTH PDISPNYDER ASYDVNDRDN  60
   61 DPMPRYEFSD ENRHGTRCAG EVAAIFNNSL CIVGIAYNAN IGGIRMLDGD VTDAVEAASV 120
  121 GHNADYIDIY SASWGPDDDG RTVDGPAKLT RSAFEKGITM GRKGKGSIFV WASGNGGKDA 180
  181 DSCNCDGYTN SIYTLSISSA TENGNIPWYS EACSSTLATT YSSGATGEKM ILTTDLHHAC 240
  241 TNMHTGTSAS APLAAGIVAL ALEANPNLTW RDLQHIVIRT AKPINLRAGD WTTNGVGRNV 300
  301 SHSFGYGLMD AGAMVKLAKI WKKVDEQHRC RQFYPSRYKN IPNGNRLQLQ LYSDGCYGGA 360
  361 DENKVSYVEH VQAIVTLKAP KRGDLQIYLT SPSGTKSTLL TKRARDTSRS GFTDWAFMTT 420
  421 HNWGEQAAGL WILEIDNDGW DDAELVKWEL VLYGTDRETG DFGGQHASPL AVRSVQMEAT 480
  481 SSGTQYSIFH VITLVILTFS QILY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 99.0
Match: 1p8jA
Description: Furin, C-terminal domain; Furin, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity, acting on L-amino acid peptides 3.71934851453379 bayes_pls_golite062009
endopeptidase activity 3.15543200180944 bayes_pls_golite062009
peptidase activity 3.06116977101231 bayes_pls_golite062009
nerve growth factor binding 2.82265810193929 bayes_pls_golite062009
neurotrophin binding 2.36320382357038 bayes_pls_golite062009
hydrolase activity 2.05732080397524 bayes_pls_golite062009
eukaryotic cell surface binding 1.98332768179918 bayes_pls_golite062009
serine hydrolase activity 1.90036575189745 bayes_pls_golite062009
serine-type peptidase activity 1.89198766955068 bayes_pls_golite062009
serine-type endopeptidase activity 1.23150012549143 bayes_pls_golite062009
binding 1.08901362883653 bayes_pls_golite062009
cell surface binding 0.65732237084615 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009
protease binding 0.53239948404232 bayes_pls_golite062009
protein binding 0.380935140681308 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle