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View Structure Prediction Details

Protein: nhr-31
Organism: Caenorhabditis elegans
Length: 583 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-31.

Description E-value Query
Range
Subject
Range
gi|10197985 - gi|10197985|gb|AAG15127.1| nuclear receptor NHR-31 [Caenorhabditis elegans]
420.0 [0..1] [583..13]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQLDVEDWE YWGDEYLEEE PTYAIRPGTR VVKVERVPMM RGDLRTSGAT SSSGPATSYI  60
   61 IRPSDKQPTV SSGGSQNGDS VCAVCGDGIA KLHYGVLACY GCKGFFRRTL TGKYRYACRF 120
  121 SNNCIVDKFQ RNSCRYCRFQ RCIQAGMDPK AVRPDRDQTG KQKVPRIKKK QIDEELLNHM 180
  181 MRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.0
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [184-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGDDWSRKLP VETRILLMQL MSIEDKVVKG DNNMSAQNTA KDPKSISLRE MFESKPALDG  60
   61 RRMEIGYEPF RMARTEELGV IAHRRAIAAV DWVDSLTEIA DAVDTEDKVA LVKSCYSPLT 120
  121 IFNFSARTAQ NTKNPDILCL CSHSFVPRRL PPEFNETNHL SNFLIDRTLN ELVAPLRKLN 180
  181 LKEEEIVPLK AIIILNPNAK GLSEHARHAI SELRDKVQDM LFQIVKELHP IYSASSRFGN 240
  241 LLLLLPTITT LSGLMSENMH FCQALGGRAS GDNLLAEMFG DRTFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.30103
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
transcription repressor activity 3.83878598697109 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription activator binding 2.98235973123409 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
receptor activity 2.62895787183554 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
steroid hormone receptor activity 2.30195937604451 bayes_pls_golite062009
transcription coactivator activity 2.27959329058894 bayes_pls_golite062009
molecular transducer activity 2.04709877069886 bayes_pls_golite062009
signal transducer activity 2.04709877069886 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
ecdysteroid hormone receptor activity 1.71585537346083 bayes_pls_golite062009
nuclear hormone receptor binding 1.60419100774741 bayes_pls_golite062009
retinoic acid receptor binding 1.59968001933699 bayes_pls_golite062009
retinoid X receptor binding 1.45560845709347 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
promoter binding 1.28787959668198 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 1.23181585568439 bayes_pls_golite062009
transcription corepressor activity 0.995333369475571 bayes_pls_golite062009
hormone receptor binding 0.95284349923679 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
structure-specific DNA binding 0.47826452126899 bayes_pls_golite062009
lipid binding 0.475303782949439 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
double-stranded DNA binding 0.42652610679613 bayes_pls_golite062009
receptor binding 0.418843034756825 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [469-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQLISSSISP PLFENPAEIC LESISPPMSD RRFVRRVDVA TQTNDDLLSS GPYLPHSNSC  60
   61 SSMLNAGYSP PMLSTSPFPL LDDNDSAFQN DISLTELNGC EEFFSQLMDQ PIIDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle