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View Structure Prediction Details

Protein: eif-3.E
Organism: Caenorhabditis elegans
Length: 432 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eif-3.E.

Description E-value Query
Range
Subject
Range
gi|17389740 - gi|17389740|gb|AAH17887.1| Eukaryotic translation initiation factor 3, subunit E [Homo sapiens]
447.0 [0..1] [431..1]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM IDSVIETYNG  60
   61 KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM MDNNRERDGN VRILEHLTQN 120
  121 HNFTVDMVDT LFKYSKFMYE 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 73.161151
Match: PF09440.1
Description: No description for PF09440.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [141-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGNYTVASVC LYYYRNLVNQ ADPNYLNALY GKLASEILLQ EWEHARDDLL KLRAYIDANP  60
   61 FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ PYLNAIQVLA PHLLRYLAVA 120
  121 VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [301-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT IEMLARRLNM  60
   61 SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH EQVMENTKRL TLRAQQIALQ 120
  121 LEKGRQDKVK AT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.14888099231537 bayes_pls_golite062009
DNA binding 4.75748996637652 bayes_pls_golite062009
nucleic acid binding 4.59221092058767 bayes_pls_golite062009
transcription factor activity 4.04817135189241 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.40118478364681 bayes_pls_golite062009
transcription activator activity 2.23968345764004 bayes_pls_golite062009
transcription repressor activity 2.12651159396305 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.31063361175854 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.2152419300113 bayes_pls_golite062009
RNA binding 0.992043085614693 bayes_pls_golite062009
transcription factor binding 0.78051974537344 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
structural constituent of ribosome 0.742648546865457 bayes_pls_golite062009
structural molecule activity 0.740044103478869 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle