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View Structure Prediction Details

Protein: calu-1
Organism: Caenorhabditis elegans
Length: 314 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for calu-1.

Description E-value Query
Range
Subject
Range
gi|50748592 - gi|50748592|ref|XP_421316.1| PREDICTED: similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase,...
202.0 [0..132] [294..506]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVLLFVGLL AATALASHHS SDPSKDGEHF KGKEHDKKYD HEQFLGKDTA AEFDELTPEK  60
   61 SKEKLAKLVP KMDADSDGFI EENELKDHIN FMQKRYVNND VDRTWKNYKA EKIVDGKIKW 120
  121 EDYREMVYGS ADGAGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1ak8A
Description: NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.31749029935893 bayes_pls_golite062009
cytoskeletal protein binding 1.5869787076114 bayes_pls_golite062009
transcription regulator activity 1.17176381524504 bayes_pls_golite062009
protein binding 1.06263369232144 bayes_pls_golite062009
calcium ion binding 1.03474411638676 bayes_pls_golite062009
nucleic acid binding 0.849623084382492 bayes_pls_golite062009
DNA binding 0.75153529115438 bayes_pls_golite062009
ion binding 0.748522810620974 bayes_pls_golite062009
cation binding 0.747391827600734 bayes_pls_golite062009
metal ion binding 0.747391827600734 bayes_pls_golite062009
actin binding 0.637627956875516 bayes_pls_golite062009
structural molecule activity 0.535595267695359 bayes_pls_golite062009
motor activity 0.35554808768187 bayes_pls_golite062009
transcription factor binding 0.02456682442567 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [137-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELSPEYAKMI ARDEKRWAVA DYDSNGALDR TEYGCFMHPE DCDHMRDVVV AETVDDIDKN  60
   61 KDGSVDLDEY IGDMYRPDDY PELNGKEPDW VQSEREMFKE HRDKDGDGKL NQEEMRDWIM 120
  121 PVGFDHAEAE ARHLVGIADD NKDGKLNLDE IVAHYDTFVG SQATDYGEQL QKHDPAEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.30103
Match: 2f2oA
Description: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle