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View Structure Prediction Details

Protein: lin-31
Organism: Caenorhabditis elegans
Length: 237 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-31.

Description E-value Query
Range
Subject
Range
gi|109083400 - gi|109083400|ref|XP_001086449.1| PREDICTED: similar to forkhead box A1 [Macaca mulatta]
186.0 [0..6] [237..354]
gi|76632539 - gi|76632539|ref|XP_599153.2| PREDICTED: similar to forkhead box A2 [Bos taurus]
184.0 [0..16] [235..349]
FXA4B_XENLA - Forkhead box protein A4-B OS=Xenopus laevis GN=foxa4-b PE=2 SV=1
176.0 [0..2] [237..108]
gi|3132705, gi|1... - gi|3132705|gb|AAC16333.1| fork head domain protein [Salmo salar], gi|185132786|ref|NP_001117001.1| f...
173.0 [0..1] [237..22]
FOXA4_XENTR - Forkhead box protein A4 OS=Xenopus tropicalis GN=foxa4 PE=2 SV=1
173.0 [0..2] [237..108]
gi|73963239 - gi|73963239|ref|XP_852354.1| PREDICTED: similar to forkhead box A1 [Canis familiaris]
170.0 [0..6] [237..163]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRPGKDSYD EQKPPYSYIW LTYMAIQDSD DKMLPLTEIY KYIMDRFPFY RKNTQRWQNS  60
   61 LRHNLSFNDC FIKIPRRADR PGKGSYWAVH PNASGMFENG SCLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 1d5vA
Description: Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [105-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRKRFRARGG QDDDDDDFHH PAPSKISRKN PLPLLPEPPI TPPLLSSLFP NLPPSLPNFC  60
   61 LFPPGMDPTK SLLLNPLSLL LMPHFLKNSS NFESSTPHSE TSEISGSGSS SSKTPTPEAG 120
  121 FNSSFSIESI LSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle