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View Structure Prediction Details

Protein: nhx-6
Organism: Caenorhabditis elegans
Length: 634 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhx-6.

Description E-value Query
Range
Subject
Range
gi|73970025 - gi|73970025|ref|XP_531775.2| PREDICTED: similar to Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger...
422.0 [0..1] [629..5]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLIRRLSVV LIGLLLILGY AQAECDEKEE EVFPSRYPIA YFKWEEVKIP MTICLWLIAA  60
   61 SISKIVFNSI PHLNDLFPDS ALLIMIGLII GIIFKLIGVD KNQFFL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [107-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESEIFMLYLL PPLVFDAGYF MPARQFFDNF GSIMCFAMIG TLFNFLAISF SLWAISLTGL  60
   61 FSVETPLLHM LLFGSVAADV DPVAVIVIFE ELAVNDVLFI AVFGESLFND GVSVVLYRMF 120
  121 LTFSEIGAEN LIPEDFANGG VSFLVVVFGG VGIGVLFAFL ASLLTKYSRA EEISILNCVF 180
  181 ILILPYTCYL CGELFGLSSI IAVVFCGALM RQYCRENVEQ ETVKATEKFI KVLSIASETV 240
  241 IFVFLGLSTV SSNHHWDTCF IVLTVVFCLI YRTLGVVVMC HFLNKYRLNK YTKVDQFIMA 300
  301 YGGLRGAIAY GLVVAIPDFI PAKNMFVTSC IIVIYFTVFL QGITLKPIAE FLQVEKKNV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 1zcdA
Description: Crystal structure of the Na+/H+ antiporter NhaA
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [466-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSKNMIEHIY TELIDTTMAG MEDIAGFKGH HWIRDSWNYF NNCYLRPVLV NKNNMKQMDK  60
   61 TKLVRKYKHL VDEDAKKIAN GGDLKSNLAF TRALIEHTRS RTNTAITSDS NGKIDFVTHM 120
  121 KEHHGITVYD HENNVEYTSD YMENESEDGE YKNGGFESDG SSDNFEERV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.49
Match: 1rw6A
Description: human APP core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.38049042607606 bayes_pls_golite062009
protein binding 0.910693622624617 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle