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View Structure Prediction Details

Protein: nhr-46
Organism: Caenorhabditis elegans
Length: 528 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-46.

Description E-value Query
Range
Subject
Range
gi|76631078 - gi|76631078|ref|XP_887036.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
273.0 [0..1] [528..1]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSDWSTDFF HQSQTPNPYP PIVQQQQQPP HTSSSFFNTN HQLNSHYSSP IHQPPTSLHQ  60
   61 PIPMMQNQFK ASPPQSDQET APTTPGSGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGQMKGERCV GCGSESAIRV HYGASSCHGC KAFFRRSVFE GRVYMCSADN HCDITNESRN  60
   61 RCRACRLRNC LEGGMNPKHV REERSKIERM PGNTCTVSAA NGVSHSSSAA SASPEHKFSF 120
  121 SLSTIAPSTS TGSFSSGSQP APIEST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
binding 0.270879137859077 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [236-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSGSEAEVL DRKLIQENQL TLFMVALEKQ TEQLTDDDVK DNDVMGAWSR DITLTFGLQH  60
   61 PQMVIKRLPL KYSCDRIMEA ADLYLSWYRS FVFAADWAMG IPEFRVLPLA DQTTLFKQNF 120
  121 MAFGWITFAY KCFELKQHLT GMPLGNGAYI PYNDEDQKKL PERWAQTYGV VCRKLIDLIV 180
  181 KAMIELQITE EEYCLIKTIS LFQQDCILSE AGQGICSRMR DRLLDALSAH IEKRYPYHTT 240
  241 SQRMTRALKI SLMLPSFSHI GQVESTLITQ LTAADLHQLS GVPMEICTAQ TTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15996699473685 bayes_pls_golite062009
transcription regulator activity 0.46162010671465 bayes_pls_golite062009
protein binding 0.33427459029264 bayes_pls_golite062009
nucleic acid binding 0.15459949087509 bayes_pls_golite062009
DNA binding 0.14395376162921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle