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View Structure Prediction Details

Protein: CE06742
Organism: Caenorhabditis elegans
Length: 481 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE06742.

Description E-value Query
Range
Subject
Range
gi|73987252 - gi|73987252|ref|XP_533935.2| PREDICTED: similar to Transcription initiation factor IIF alpha subunit...
258.0 [0..1] [475..102]

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Predicted Domain #1
Region A:
Residues: [1-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLKPVKPE GVQSEFSVRV AKRSDDIRYS VMMFNGMDKV DTSKWTIDSG VTMEREDNQR  60
   61 VILSTQTVQE YGEGSEYGKA AREEARRKKY GRQSKKYRLD NQPWKMAFTE PEGRQRQMRG 120
  121 IREGGANEHA DYWVFLKPNQ SSEFKAYKVD EWHKFLPAIT HKTLDIDQAE EQFSQRYKVM 180
  181 NQFALKAAIQ N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1f3uB
Description: TFIIF alpha subunit, Rap74
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.635056919936313 bayes_pls_golite062009
transcription regulator activity 0.39007787114886 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.33823097458615 bayes_pls_golite062009
protein binding 0.036066227704511 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [192-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLSATDESEM TEQQKRLLKI KDEASSDDSD GDDEGEGGDD GKKAKNKKKK KKNAKPAKEK  60
   61 RQRVEDKDDV AKYESSDGED EGREYDYISD SGTDSDREQV PSDEKIEKQL VGVAEEEGAR 120
  121 ESDSSESEDD LTKKLMKPYG DKKKGNDIEE RDSSGTDSDV SDTEKLDSVV FMKANKDGEG 180
  181 G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [373-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGTGKKRPP TEDSDLKMDN LGPSDAKKAK PAVKFEEGLN EETVRRYLRR KPHTTKELLH  60
   61 KMNGKCGNMS KSEMVTQLAS ILKAIEPNQS RQLKGKKEVL FFSLVNTIA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.154902
Match: 1nhaA
Description: C-terminal domain of the rap74 subunit of TFIIF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.04426015975991 bayes_pls_golite062009
binding 1.99063774159045 bayes_pls_golite062009
DNA binding 1.63968725174405 bayes_pls_golite062009
nucleic acid binding 1.51035375793093 bayes_pls_golite062009
transcription factor activity 1.16072080355661 bayes_pls_golite062009
transcription activator activity 0.14130464856269 bayes_pls_golite062009
sequence-specific DNA binding 0.13573040816325 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle