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View Structure Prediction Details

Protein: sir-2.1
Organism: Caenorhabditis elegans
Length: 607 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sir-2.1.

Description E-value Query
Range
Subject
Range
SIR2_CAEBR - NAD-dependent protein deacetylase sir-2.1 OS=Caenorhabditis briggsae GN=sir-2.1 PE=3 SV=1
428.0 [0..1] [607..1]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSGNDSE VAVTHGEVQE ITEENPEIGS MHITQETDIS DAPETNTDSS RQRTESTTSV  60
   61 SSESWQNNDE MMSNLRRAQR LLDDGATPLQ IIQQIFPDFN ASRIATMSEN AHF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [114-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AILSDLLERA PVRQKLTNYN SLADAVELFK TKKHILVLTG AGVSVSCGIP DFRSKDGIYA  60
   61 RLRSEFPDLP DPTAMFDIRY FRENPAPFYN FAREIFPGQF VPSVSHRFIK ELETSGRLLR 120
  121 NYTQNIDTLE HQTGIKRVVE CHGSFSKCTC TRCGQKYDGN EIREEVLAMR VAHCKRCEGV 180
  181 IKPNIVFFGE DLGREFHQHV TEDKHKVDLI VVIGSSLKVR PVALIPHCVD KNVPQILINR 240
  241 ESLPHYNADI ELLGNCDDII RDICFSLGGS FTELI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.09691
Match: 1j8fA
Description: Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 9.15022242957651 bayes_pls_golite062009
histone deacetylase activity 9.04876491350231 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 8.13038616303736 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 8.13038616303736 bayes_pls_golite062009
deacetylase activity 8.11496387956068 bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific) 6.02509672218091 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5.83127897351395 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific) 5.29340754009793 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific) 5.29340754009793 bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific) 4.51070381823692 bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific) 3.4896257195243 bayes_pls_golite062009
transcription regulator activity 2.9155913558118 bayes_pls_golite062009
DNA binding 2.43141001866996 bayes_pls_golite062009
nucleic acid binding 2.41433477472968 bayes_pls_golite062009
transcription repressor activity 2.24657784428979 bayes_pls_golite062009
binding 2.06552694538163 bayes_pls_golite062009
histone binding 1.71445510915336 bayes_pls_golite062009
transcription corepressor activity 1.64212790017753 bayes_pls_golite062009
protein binding 1.52593340148652 bayes_pls_golite062009
nucleosome binding 1.5125174755597 bayes_pls_golite062009
hydrolase activity 1.43067365161346 bayes_pls_golite062009
transcription factor activity 1.30143289828088 bayes_pls_golite062009
transcription factor binding 1.14766678956419 bayes_pls_golite062009
tubulin deacetylase activity 1.11434618720209 bayes_pls_golite062009
catalytic activity 0.739210399081789 bayes_pls_golite062009
transcription cofactor activity 0.54005617175343 bayes_pls_golite062009
transferase activity 0.483523935618287 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.114062221123972 bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity 0.0099486881187274 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [389-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSYDSIMEQQ GKTKSQKPSQ NKRQLISQED FLNICMKEKR NDDSSDEPTL KKPRMSVADD  60
   61 SMDSEKNNFQ EIQKHKSEDD DDTRNSDDIL KKIKHPRLLS ITEMLHDNKC VAISAHQTVF 120
  121 PGAECSFDLE TLKLVRDVHH ETHCESSCGS SCSSNADSEA NQLSRAQSLD DFVLSDEDRK 180
  181 NTIHLDLQRA DSCDGDFQYE LSETIDPETF SHLCEEMRI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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