YRC Public Data Repository - Protein Structure Prediction

Protein:	pyp-1
Organism:	Caenorhabditis elegans
Length:	292 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pyp-1.

Description	E-value	Query Range	Subject Range
pyp-1 - inorganic pyrophosphatase status:Confirmed UniProt:Q18680 protein_id:CAD89726.1	384.0	[0..1]	[292..116]
gi\|109089533 - gi\|109089533\|ref\|XP_001107614.1\| PREDICTED: similar to pyrophosphatase 1 [Macaca mulatta]	374.0	[0..5]	[289..197]
gi\|32409301, gi\|... - gi\|32409301\|ref\|XP_325131.1\| hypothetical protein [Neurospora crassa], gi\|28926948\|gb\|EAA35908.1\| hy... gi\|85116947 - gi\|85116947\|ref\|XP_965144.1\| hypothetical protein [Neurospora crassa OR74A]	371.0	[0..2]	[292..176]
gi\|66852413, gi\|... - gi\|71000118\|ref\|XP_754776.1\| inorganic diphosphatase [Aspergillus fumigatus Af293], gi\|66852413\|gb\|E... gi\|159127784 - gi\|159127784\|gb\|EDP52899.1\| inorganic diphosphatase, putative [Aspergillus fumigatus A1163]	367.0	[0..11]	[292..111]
gi\|157756985 - gi\|157756985\|ref\|XP_001670836.1\| Hypothetical protein CBG03439 [Caenorhabditis briggsae AF16] gi\|187036659, gi... - gi\|39585749\|emb\|CAE59951.1\| Hypothetical protein CBG03439 [Caenorhabditis briggsae], gi\|187036659\|em...	365.0	[0..1]	[292..59]
gi\|145020555, gi... - gi\|39951911\|ref\|XP_363672.1\| inorganic pyrophosphatase [Magnaporthe grisea 70-15], gb\|EAA55947.1\| hy...	363.0	[0..7]	[292..1]
IPYR_YARLI - Inorganic pyrophosphatase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=IPP1 PE=3 SV=1 IPYR_YARLI - Inorganic pyrophosphatase OS=Yarrowia lipolytica GN=IPP1 PE=3 SV=1	362.0	[0..8]	[292..1]
IPYR_DEBHA - Inorganic pyrophosphatase OS=Debaryomyces hansenii GN=IPP1 PE=3 SV=1 IPYR_DEBHA - Inorganic pyrophosphatase OS=Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 00...	361.0	[0..11]	[292..3]

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Predicted Domain #1

Region A:
Residues: [1-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTGAGDSAV YEAVERGSLY SLDYRVYIKG PQGIVSPWHD IPLFANKDKR VYNMIVEIPR  60
   61 WTNAKMEMAT KEPFSPIKQD EKKGVARFVH NIFPHKGYIW NYGALPQTWE DPNHVVPDTG 120
  121 AKGDNDPIDV IEVGSKVAGR GAVLQVKVLG TLALIDEGET DWKLVAIDVN DENADKLNDI 180
  181 DDVEKVYPGL LAASVEWFRN YKIPAGKPAN EFAFNGEFKN REYAEKVIDE TNEYWKTLIK 240
  241 EANPSLNTVS RVPEAVHQGT DEAAATAIGA TPEHGANAPL PGDVDKWHFV QG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	98.221849
Match:	1e6aA
Description:	Inorganic pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
inorganic diphosphatase activity	2.74116819406619	bayes_pls_golite062009
binding	1.77492613217844	bayes_pls_golite062009
catalytic activity	1.33262120571864	bayes_pls_golite062009
protein binding	0.38607803003281	bayes_pls_golite062009
pyrophosphatase activity	0.354425639853757	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.334860448536013	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.333575715544697	bayes_pls_golite062009
hydrolase activity	0.0110854177718558	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: