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View Structure Prediction Details

Protein: egl-38
Organism: Caenorhabditis elegans
Length: 289 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for egl-38.

Description E-value Query
Range
Subject
Range
pax-2 - paired box transcription factor status:Partially_confirmed UniProt:Q21263 protein_id:AAA93452.2
319.0 [0..19] [289..81]
gi|34878716 - gi|34878716|ref|NP_003980.2| paired box protein 2 isoform d [Homo sapiens]
286.0 [0..15] [284..1]
gi|37575437 - gi|37575437|gb|AAQ93683.1| Pax protein [Caenorhabditis briggsae]
285.0 [0..1] [287..4]
gi|73998649 - gi|73998649|ref|XP_851539.1| PREDICTED: similar to paired box protein 2 isoform c [Canis familiaris]
284.0 [0..1] [284..361]
gi|4377879 - gi|4377879|gb|AAD19294.1| paired box protein pax2.1 splice variant [Danio rerio]
282.0 [0..15] [284..1]
gi|45382169, gi|... - gi|6683012|dbj|BAA88987.1| paired-box containing protein Pax-2 [Gallus gallus], gi|45382169|ref|NP_9...
281.0 [0..15] [284..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPIWRNYPY PTYPGHHNFQ FDPLLSDGSH TGVNQLGGVF VNGRPLADTV RAQIVEMSQH  60
   61 GTRPCDISRQ LKVSHGCVSK ILGRYYSTGS VRPGVIGGSK PKVATPRVVE CIAGYKRANP 120
  121 TMFAWEIRQK LIEDQICGEE NVPSVSSINR IVRNKSFMAQ L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.39794
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [162-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAPTSVTSSA ARPSSATSHH QRSPPRGVQQ HMQQSTSVQQ LQQLQLTSAA TVNSLMTPPA  60
   61 FAMPGTAYSI NGLLGTLPQP SLLDDKFTNL STQSADMSLV YSTGLVGEHD WTMRTPMVIL 120
  121 PQNYCGQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle