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View Structure Prediction Details

Protein: sphk-1
Organism: Caenorhabditis elegans
Length: 473 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sphk-1.

Description E-value Query
Range
Subject
Range
gi|187030622, gi... - gi|39582738|emb|CAE65944.1| Hypothetical protein CBG11121 [Caenorhabditis briggsae], gi|187030622|em...
257.0 [0..1] [473..1]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFIVVVTIFE NYTQWYSSLL TIFSLTIKRK LKTIRSMQDS TSKCTCTEHH MGGTICCCCR  60
   61 SDAEENEQLT SVILSRKPPP QEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1r79A
Description: Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
diacylglycerol kinase activity 2.90473448739823 bayes_pls_golite062009
binding 2.36195429973813 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
GTPase regulator activity 1.39167263636091 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.38342442442381 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.37139209958305 bayes_pls_golite062009
kinase activity 1.33864137110482 bayes_pls_golite062009
transcription regulator activity 1.33317387103526 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.1573242399369 bayes_pls_golite062009
enzyme regulator activity 0.911061212692491 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.907368864863833 bayes_pls_golite062009
nucleic acid binding 0.826306657093297 bayes_pls_golite062009
transferase activity 0.758542436038668 bayes_pls_golite062009
DNA binding 0.717144137601851 bayes_pls_golite062009
small GTPase regulator activity 0.661240850692236 bayes_pls_golite062009
protein kinase activity 0.565178270477957 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.50008268869921 bayes_pls_golite062009
protein serine/threonine kinase activity 0.418610537312063 bayes_pls_golite062009
transcription factor activity 0.201999701332224 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0643193071226404 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [84-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRGNLLVFIN PNSGTGKSLE TFANTVGPKL DKSLIRYEVV VTTGPNHARN VLMTKADLGK  60
   61 FNGVLILSGD GLVFEALNGI LCREDAFRIF PTLPIGIVPS GSGNGLLCSV LSKYGTKMNE 120
  121 KSVMERALEI ATSPTAKAES VALYSVKTDN QSYASFLSIG WGLMADIDID SEKWRKSLGH 180
  181 HRFTVMGFIR SCNLRSYKGR LTYRPYKPKG FHPSSNVFSV YEKTTQQRID DSKVKTNGSV 240
  241 SDSEEETMET KFQNWTLPDS DETLAVGSSD LEETVVIEDN FVNIYAVTLS HIAADGPFAP 300
  301 SAKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.522879
Match: 2bonA
Description: No description for 2bonA was found.

Predicted functions:

Term Confidence Notes
kinase activity 2.76633393386992 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.49560915337842 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.43985991144271 bayes_pls_golite062009
transferase activity 1.63159199531284 bayes_pls_golite062009
catalytic activity 0.33446102778142 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [388-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDNRIHLSYI LWKDIGTRVN IAKYLLAIEH ETHLDLPFVK HVEVSSMKLE VISEGSHVVL  60
   61 DGEVVDTKTI EVASTKNHIS VFSSTA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.31
Match: 2bonA
Description: No description for 2bonA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle