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View Structure Prediction Details

Protein: daf-7
Organism: Caenorhabditis elegans
Length: 350 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-7.

Description E-value Query
Range
Subject
Range
GDF8_MELGA - Growth/differentiation factor 8 OS=Meleagris gallopavo GN=MSTN PE=2 SV=2
258.0 [0..2] [350..3]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFMASSLPVF IFLLSLPHGL TFNCTNSGVC IEKMKQHRTE YLKNEILDQL NMKEAPKGLK  60
   61 PMDPEMKSVY LEMYRDLLEK DEQDMGVEMS FYTAKDP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [98-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYGENPSQLV AKFDVTNDLE RSDILQATLT VSIEIPAKDS GMLQDVQVQV YEKNEDGSMG  60
   61 EMVTSGIFAT KGSERISIQL PIDTVKSWFT ISPIQGIFVK AMLDGRNVAL HPQQTTADVD 120
  121 NMRLQLST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [226-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPKGSRKRRS HAKPVCNAEA QSKGCCLYDL EIEFEKIGWD WIVAPPRYNA YMCRGDCHYN  60
   61 AHHFNLAETG HSKIMRAAHK VSNPEIGYCC HPTEYDYIKL IYVNRDGRVS IANVNGMIAK 120
  121 KCGCS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
type II transforming growth factor beta receptor binding 8.13965462870591 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 7.85857332663967 bayes_pls_golite062009
platelet-derived growth factor receptor binding 6.4684557744685 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 5.9885816311386 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 5.13799972612867 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
cytokine activity 4.8098396386842 bayes_pls_golite062009
growth factor activity 4.74498867224238 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
protein binding 3.41839891062651 bayes_pls_golite062009
fibronectin binding 3.36540670741416 bayes_pls_golite062009
binding 3.28090754728074 bayes_pls_golite062009
growth factor binding 3.23153419905493 bayes_pls_golite062009
glycosaminoglycan binding 3.12262133458315 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
heparin binding 2.81661725670177 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 2.42595321135263 bayes_pls_golite062009
polysaccharide binding 2.42568523771453 bayes_pls_golite062009
transcription regulator activity 2.31616116370197 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
platelet-derived growth factor binding 2.01091405432331 bayes_pls_golite062009
protein dimerization activity 1.82426827198541 bayes_pls_golite062009
transcription repressor activity 1.69276038320301 bayes_pls_golite062009
transcription activator activity 1.63851701049695 bayes_pls_golite062009
collagen binding 1.56562537405529 bayes_pls_golite062009
protein kinase activity 1.41847295970293 bayes_pls_golite062009
molecular transducer activity 1.40678896068326 bayes_pls_golite062009
signal transducer activity 1.40678896068326 bayes_pls_golite062009
protein homodimerization activity 1.377005150119 bayes_pls_golite062009
protein heterodimerization activity 1.19300119957916 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.19169017348435 bayes_pls_golite062009
identical protein binding 1.18858126900765 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.1841101716474 bayes_pls_golite062009
kinase activity 1.15484804727089 bayes_pls_golite062009
cytokine binding 1.11655568277071 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.772832351269279 bayes_pls_golite062009
protein serine/threonine kinase activity 0.675252100191059 bayes_pls_golite062009
neurotrophin TRK receptor binding 0.552075777293301 bayes_pls_golite062009
neurotrophin TRKB receptor binding 0.552075777293301 bayes_pls_golite062009
transforming growth factor beta binding 0.539891088283499 bayes_pls_golite062009
beta-amyloid binding 0.51409569546989 bayes_pls_golite062009
SMAD binding 0.195453215953383 bayes_pls_golite062009
specific transcriptional repressor activity 0.1719107348851 bayes_pls_golite062009
follicle-stimulating hormone activity 0.126261994098681 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

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Created and Maintained by: Michael Riffle