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View Structure Prediction Details

Protein: tbx-2
Organism: Caenorhabditis elegans
Length: 423 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tbx-2.

Description E-value Query
Range
Subject
Range
gi|68371916 - gi|68371916|ref|XP_689261.1| PREDICTED: similar to brachyury transcription factor [Danio rerio]
340.0 [0..33] [423..355]

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Predicted Domain #1
Region A:
Residues: [1-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFNPFALGR PDLLLPFMGA GVGGPGAGGP PPNLFFSMLQ AGFPPGPVGS PPEDDGVTDD  60
   61 PKVELDEREL WQQFSQCGTE MVITKSGRRI FPAYRVKISG LDKKSQYFVM MDLVPADEHR 120
  121 YKFNNSRWMI AGKADPEMPK TLYIHPDSPS TGEHWMSKGA NFHKLKLTNN ISDKHGYTIL 180
  181 NSMHKYQPRL HVVRCADRHN LMYSTFRTFV FRETEFIAVT AYQNEKVTEL KIENNPFAKG 240
  241 FRDAGAGKRE KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.522879
Match: 1h6fA
Description: T-box protein 3, tbx3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.29102864831653 bayes_pls_golite062009
transcription regulator activity 1.92025295308511 bayes_pls_golite062009
DNA binding 1.86143461884692 bayes_pls_golite062009
nucleic acid binding 1.68075928646599 bayes_pls_golite062009
transcription factor activity 1.33446362838411 bayes_pls_golite062009
protein binding 0.74749676675118 bayes_pls_golite062009
sequence-specific DNA binding 0.47331695689559 bayes_pls_golite062009
transcription activator activity 0.33290695293257 bayes_pls_golite062009
DNA strand annealing activity 0.0812057721813604 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [253-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQLHRMNGDA TQSPPGKTAS LPTHSPHPSE SNSEDDEPTL KKCKPEPSQT PTTSSLSTST  60
   61 TPTLSAHHPL RSPQFCIPPP IDMMYQNMPM DLLAHWQMAT LFPQFSMALN SPAAAASLLS 120
  121 KHLAKASSEC KVEATSEDSE EAEKPEVKKE QKSVTPPKKG GFDVLDLLSK P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle