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View Structure Prediction Details

Protein: cdka-1
Organism: Caenorhabditis elegans
Length: 366 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdka-1.

Description E-value Query
Range
Subject
Range
gi|187025084, gi... - gi|39591589|emb|CAE71166.1| Hypothetical protein CBG18023 [Caenorhabditis briggsae], gi|187025084|em...
gi|157775211 - gi|157775211|ref|XP_001665671.1| hypothetical protein CBG18023 [Caenorhabditis briggsae AF16]
619.0 [0..1] [364..1]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGANLTSPLP HHHRTQTTSV CNHLFSPGDG GPTFAPQRDS NTSSRSSSNA KESVLMQGWN  60
   61 WSKRNIQPVM SRRSLPKSGS SSEATSSKSS DSLVSFTRNV STSTSSQYGK ISISLDRNQN 120
  121 YKSVPRPSDT TTIIPNYYSL REEFRRGLQI NTRQDLVNNN LASNDLSVIG SPKHVPRPRS 180
  181 VLRDDNANCD 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.823909
Match: PF03261.6
Description: No description for PF03261.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISPIAEQENV PSEKRGTKKT IIQASTSELL RGLGIFISNN CDVSDFDPAH LVTWLRSVDR  60
   61 SLLLQGWQDI AFINPANLVF IFLLVRDVLP DERHLIHTLE ELHAWILSCL YVSYSYMGNE 120
  121 ISYPLKPFLI GNDRNTFWNR CVAMVTSHSR QMLLLNSSST FFSEVFTDLK HCSSSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.69897
Match: 1ungD
Description: Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.856796143703865 bayes_pls_golite062009
protein binding 0.73326264902081 bayes_pls_golite062009
kinase regulator activity 0.29156514721728 bayes_pls_golite062009
enzyme regulator activity 0.27414343875363 bayes_pls_golite062009
protein kinase regulator activity 0.19903417452788 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle