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View Structure Prediction Details

Protein: exc-7
Organism: Caenorhabditis elegans
Length: 456 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for exc-7.

Description E-value Query
Range
Subject
Range
gi|76633735 - gi|76633735|ref|XP_881462.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 1 isoform 6 ...
254.0 [0..33] [455..2]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMEALLTPN NNNVPTSPVQ TTYTSTQRYC SAPNVDIGES KTNLIINYLP QGMTQEEVRS  60
   61 LFTSIGEIES CKLVRDKVTG QSLGYGFVNY VREEDALRAV SSFNGLRLQN KTIKVSYARP 120
  121 SNDQIKGSNL YVSGIPKSMT LHELESIFRP FGQIITSRIL SDNVTGLSKG VGFVRFDKKD 180
  181 EADVAIKTLN GSIPSGCSEQ ITVKFAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 1fxlA
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.83802439076672 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
poly-pyrimidine tract binding 1.69629099229571 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
mRNA 5'-UTR binding 0.625848256054783 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.461000905454505 bayes_pls_golite062009
structure-specific DNA binding 0.43716526938634 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
snRNA binding 0.249682711188639 bayes_pls_golite062009
single-stranded DNA binding 0.2202184446161 bayes_pls_golite062009
structural molecule activity 0.166336846372115 bayes_pls_golite062009
translation regulator activity 0.117211881967154 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [208-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPASNNPKGL LSDLEAVQQA ATTLVPLSTI LGAPTLRATA GGIGPMHHAP ITSKYRYSPM  60
   61 GAITAVSQPT ATLPADYLTT SALLQMSQLN ALAGLNPFAT ATAVPDFTAS LIAHQQQQHA 120
  121 VAQQHAAQTA SPPATNGQVA GLAAHAQLSA LSASVAAT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [366-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPSDTAGYC LFVYNLSSDT DDTLLWQLFS QFGAIVNVKI LRDLTQQCKG YAFVSMSNYT  60
   61 EAYNAMLSLN GTNLAGKTLQ VVFKSSTPYR A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 2d9pA
Description: No description for 2d9pA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle