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View Structure Prediction Details

Protein: mig-10
Organism: Caenorhabditis elegans
Length: 650 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mig-10.

Description E-value Query
Range
Subject
Range
gi|56207000 - gi|56207000|emb|CAI24283.1| ortholog of human Ras association (RalGDS\/AF-6) and pleckstrin homology...
590.0 [0..10] [505..69]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYHDRRRTGF RQYETYMKQK QSADWQLDEL LEELEALETQ LNSSNGGDQL LLGVSGIPAS  60
   61 SSRENVKSIS TLPPPPPALS YHQTPQQPQL LHHHNNHLGY QNGIHQITSI NSAASSCSSP 120
  121 DGDSAFGDSS STESSNNRCR NSAFSSNDSC RDSLNTPSPT QVSPR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGELNAEEAK AQKIRQALEK MKEAKVTKIF VKFFVEDGEA LQLLIDERWT VADTLKQLAE  60
   61 KNHIALMEDH CIVEEYPELY IKRVYEDHEK VVENIQMWVQ DSPNKLYFMR RPDKYAFISR 120
  121 PELYLLTPKT SDHMEIPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1wgrA
Description: Solution Structure of the RA Domain of Human Grb7 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.0934358341245259 bayes_pls_golite062009
protein binding 0.03789551947602 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [304-450]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDQWTIDVKQ KFVSEYFHRE PVVPPEMEGF LYLKSDGRKS WKKHYFVLRP SGLYYAPKSK  60
   61 KPTTKDLTCL MNLHSNQVYT GIGWEKKYKS PTPWCISIKL TALQMKRSQF IKYICAEDEM 120
  121 TFKKWLVALR IAKNGAELLE NYERACQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2yryA
Description: No description for 2yryA was found.

Predicted Domain #4
Region A:
Residues: [451-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRRETLGPAS SMSAASSSTA ISEVPHSLSH HQRTPSVASS IQLSSHMMNN PTHPLSVNVR  60
   61 NQSPASFSVN SCQQSHPSRT SAKLEIQYDE QPTGTIKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [549-650]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APLDVLRRVS RASTSSPTIP QEESDSDEEF PAPPPVASVM RMPPPVTPPK PCTPLTSKKA  60
   61 PPPPPKRSDT TKLQSASPMA PAKNDLEAAL ARRREKMATM EC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1mw4A
Description: Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle