YRC Public Data Repository - Protein Structure Prediction

Protein:	dml1
Organism:	Schizosaccharomyces pombe
Length:	465 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dml1.

Description	E-value	Query Range	Subject Range
gi\|73996516 - gi\|73996516\|ref\|XP_850665.1\| PREDICTED: similar to Tubulin alpha-2 chain (Alpha-tubulin 2) isoform 2...	410.0	[0..60]	[463..2]
gi\|60653689 - gi\|60653689\|gb\|AAX29538.1\| tubulin alpha 6 [synthetic construct]	410.0	[0..60]	[463..2]
gi\|62897609 - gi\|62897609\|dbj\|BAD96744.1\| tubulin alpha 6 variant [Homo sapiens]	409.0	[0..60]	[463..2]
TBA1C_MOUSE - Tubulin alpha-1C chain OS=Mus musculus GN=Tuba1c PE=1 SV=1 gi\|124481732, gi... - gi\|148225011\|ref\|NP_001091315.1\| hypothetical protein LOC100037141 [Xenopus laevis], gi\|124481732\|gb... TBA1C_CRIGR - Tubulin alpha-1C chain OS=Cricetulus griseus GN=TUBA1C PE=2 SV=1	409.0	[0..60]	[463..2]
gi\|115896498 - gi\|115896498\|ref\|XP_795276.2\| PREDICTED: similar to putative alpha-tubulin, partial [Strongylocentro...	409.0	[0..60]	[463..1]
TBA1C_RAT - Tubulin alpha-1C chain OS=Rattus norvegicus GN=Tuba1c PE=1 SV=1	409.0	[0..60]	[463..2]
gi\|109104620 - gi\|109104620\|ref\|XP_001110230.1\| PREDICTED: similar to Tubulin alpha-3 chain (Alpha-tubulin 3) [Maca...	409.0	[0..49]	[463..262]
gi\|32400724 - gi\|32400724\|gb\|AAP80594.1\|AF465692_1 putative alpha-tubulin [Oikopleura dioica]	409.0	[0..60]	[463..2]

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Predicted Domain #1

Region A:
Residues: [1-465]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHEILTVTFG RKSNFCWTHF WNTQESYFVY DPNDHAKVNV NTNFRVLKKR DPEAIVTVPR  60
   61 ECIYDTPIEF GNTRKNWLEE LNESSGGKGT AWDGKLTQIM QTPVDVHPYQ EALWSRDEIH 120
  121 EGNAIESEYE LPSIRPKSVK YWSDFNRLFL DTEYLFPVNC SELNSSDFSF QLGVERFHDF 180
  181 DKQFNVWDEG LRPLVEECDS VQGFQAAIDI DTPWGGFASE YMKVVQDELG ECRVPTWVYG 240
  241 IREPIQSDSS ATIDNHFGKL NEALSLSQLN GSCSQYFPLC TISQGDDLWA SSAKINLAIE 300
  301 SFTLPTRVYG SSCYRMKDIE SKLQSEGRGF IHNLNFKAKN YSSKEWALVS SASFVNVAQD 360
  361 YSQQNNCLFG VVRSPKDNQG LLEGKNYNAS SISKIVNIQN LGLPSLETVP EGLRTLDTVF 420
  421 VEATNDGQIN SHIQGLTKSL NRRFVSFVDQ DELEEIREIL SSYII

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1z2bA
Description:	Tubulin-colchicine-vinblastine: stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of cytoskeleton	2.03190599071485	bayes_pls_golite062009
GTPase activity	1.47429346598123	bayes_pls_golite062009
binding	1.37861013116188	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.30976970862305	bayes_pls_golite062009
pyrophosphatase activity	1.23995409691722	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.2207183653046	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.21864338056199	bayes_pls_golite062009
protein binding	0.764892815699872	bayes_pls_golite062009
structural molecule activity	0.68134435683807	bayes_pls_golite062009
hydrolase activity	0.0508375661543299	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: