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View Structure Prediction Details

Protein: sfc4
Organism: Schizosaccharomyces pombe
Length: 1006 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sfc4.

Description E-value Query
Range
Subject
Range
gi|73670079, gi|... - gi|73670079|ref|YP_306094.1| TPR repeat-containing protein [Methanosarcina barkeri str. Fusaro], gi|...
421.0 [0..56] [1000..34]
gi|33640682, gi|... - gi|33862569|ref|NP_894129.1| TPR repeat-containing protein [Prochlorococcus marinus str. MIT 9313], ...
404.0 [0..4] [997..76]
gi|113477431, gi... - gi|71673743|ref|ZP_00671491.1| TPR repeat:TPR-related region [Trichodesmium erythraeum IMS101], gi|7...
404.0 [0..6] [1005..589]
gi|21228822, gi|... - gi|21228822|ref|NP_634744.1| hypothetical protein MM_2720 [Methanosarcina mazei Go1], gi|20907343|gb...
392.0 [0..71] [1005..34]
gi|118354513 - gi|118354513|ref|XP_001010518.1| TPR Domain containing protein [Tetrahymena thermophila]
gi|118354513, gi... - gi|89292285|gb|EAR90273.1| TPR Domain containing protein [Tetrahymena thermophila SB210], gi|1183545...
388.0 [0..4] [1005..631]
gi|20093095, gi|... - gi|20093095|ref|NP_619170.1| TPR domain-containing protein [Methanosarcina acetivorans C2A], gi|1991...
379.0 [0..64] [1004..28]
gi|115699987, gi... - gi|115930468|ref|XP_001192487.1| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus], gi...
373.0 [0..1] [985..1184]
gi|126179259, gi... - gi|126179259|ref|YP_001047224.1| TPR repeat-containing protein [Methanoculleus marisnigri JR1], gi|1...
365.0 [0..6] [1005..30]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQNGGNSYV DSNMNETQND TTDNFDAEMQ DLNGYISEIV DEARNVSEVD AKFLGDTSAL  60
   61 QAEGLWSDEE SDYEGSDDES NFSKTAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTEDDIANEE WEENLKAVAG FRKVRKGHKG RGRVSRADML PSVEVQQMLS LANHLFAQEG  60
   61 NFDEAQKLAE EIVRIDNNVI AAWKMLGECH RQRGNGRVNI EKCLIAWMAA AHLKPKDHEL 120
  121 WFTCAKLSES LEFWDQADYC YNRAVSAKPP NKSELKKYIW NRSVLNKEHG SLKKAAEGFK 180
  181 FLLQSSPYNA SILKNLAEIY IKIHAPREIL KQFEIAWKYF YQYPAPPIGN DIFDLPTLNL 240
  241 YAELLLLDHQ WSNLIRLINR GVRWFRGRKS ESFWDEFDDD REWDVDERRR EFPNASEEHT 300
  301 NKEAYLLPHL FRTKLGIARL KTGELPEAEL HFSVIKNLPP DYAWGMLYDI AKAYMDIERL 360
  361 DLALEYFVLI CNHEPAQNIG LWYNMGVCYL EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.24290984515946 bayes_pls_golite062009
transcription regulator activity 2.36571535004008 bayes_pls_golite062009
protein binding 1.83529176977066 bayes_pls_golite062009
DNA binding 1.71381351716702 bayes_pls_golite062009
nucleic acid binding 1.61516860680687 bayes_pls_golite062009
transcription factor activity 1.01338808398786 bayes_pls_golite062009
transcription factor binding 0.518146612491969 bayes_pls_golite062009
transcription cofactor activity 0.30464889749774 bayes_pls_golite062009
transcription coactivator activity 0.116119418380222 bayes_pls_golite062009
transcription activator activity 0.0593768116971065 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [480-675]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEYEHAQQCM EAILIVDNSN TNALIKLAEI NELQDNRDAA LEIVTNIFEQ RRNINELERE  60
   61 QSQNEDHEKN VGSQLFVGNQ KVPQDKWEKR ARISRSKEEA RQFTIWKTEE TQRRFHKLDI 120
  121 LRQSLKKEEN VSESLNEWLA IASELIDEFV SIKAFFPSEK KARARAGLLT RRTRYASLND 180
  181 QLTSMINRLN DSLTRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1zbpA
Description: Crystal Structure of the Hypothetical protein VPA1032 from Vibrio parahaemolyticus, Northeast Structural Genomics Target VpR44
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [676-1006]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYGDLDLDTI LRTGYFRNVS IDAWYQLFVE FSLRLTKVGS VQQAYDVLTT AMGAILFDQD  60
   61 TIKRQNLRWC MLACSMYARD PQGALTPLRW VFTTFQFRQD TYRLFSAVLS QGYECSRAFV 120
  121 DSANQKFLLR LIKLMDQLMS NSLVSGAATL VKNDDGLATV PTSYDPVLVL LYGHIMARNR 180
  181 SWIPAINYYS RAFAINPDCP ITNLSLGLAY LHRAMQRLSD NRHYQILQGF TFLYRYYDLR 240
  241 VNEGLGEKQE ALYNLGKAYH FIGLEHYAVK YYEAVLGLSP MSQGDKMTSS ESTVSTTYDF 300
  301 GFEAAYNLRL IYICSGNIKL AFQISSKYLI F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 2j9qA
Description: No description for 2j9qA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle