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View Structure Prediction Details

Protein: SPBC1685.08
Organism: Schizosaccharomyces pombe
Length: 424 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1685.08.

Description E-value Query
Range
Subject
Range
gi|8163674 - gi|8163674|gb|AAF73795.1|AF154026_1 surface protein PspC [Streptococcus pneumoniae]
151.0 [0..7] [370..107]
gi|70878103 - gi|70878103|gb|EAN91386.1| trans-sialidase, putative [Trypanosoma cruzi]
gi|71648919 - gi|71648919|ref|XP_813237.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
143.0 [0..1] [403..692]
gi|24020878, gi|... - gi|50979202|ref|NP_001003352.1| neurofilament, heavy polypeptide 200kDa [Canis lupus familiaris], gi...
139.0 [0..3] [405..571]
gi|6469847 - gi|6469847|gb|AAF13456.1| unknown [Streptococcus pneumoniae]
gi|6469847 - gi|6469847|gb|AAF13456.1| unknown [Streptococcus pneumoniae]
136.0 [0..9] [370..109]
gi|25509405, gi|... - gi|8163644|gb|AAF73779.1| surface protein PspC [Streptococcus pneumoniae], pir||H98120 choline bindi...
gi|15459699, gi|... - gi|15904036|ref|NP_359586.1| choline binding protein A [Streptococcus pneumoniae R6], gi|15459699|gb...
gi|116515359, gi... - gi|8163644|gb|AAF73779.1|AF154012_1 surface protein PspC [Streptococcus pneumoniae], gi|116515359|re...
136.0 [0..9] [370..109]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSNSTPANE EKEEESEKIQ KSPVDTPHTP NGSVSDNEEN ETSSTGEVTR CVCGIVESDD  60
   61 EASDGGLYIQ CDQCSVWQHG NCVGFADESE VPEVYYCEIC HPEFHKV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1wemA
Description: Solution structure of PHD domain in death inducer-obliterator 1(DIO-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 7.50578521120904 bayes_pls_golite062009
histone deacetylase activity 7.35162059871663 bayes_pls_golite062009
deacetylase activity 6.55925777139018 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5.24378850198774 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4.39452339322141 bayes_pls_golite062009
methylated histone residue binding 4.19057851212315 bayes_pls_golite062009
histone acetyltransferase activity 3.20023500652896 bayes_pls_golite062009
lysine N-acetyltransferase activity 3.20023500652896 bayes_pls_golite062009
histone binding 3.01402804224903 bayes_pls_golite062009
binding 2.93415748500038 bayes_pls_golite062009
transcription regulator activity 2.89424169822343 bayes_pls_golite062009
DNA binding 2.67786232715949 bayes_pls_golite062009
nucleic acid binding 2.6327300364647 bayes_pls_golite062009
nucleosome binding 1.69494047037058 bayes_pls_golite062009
transcription factor activity 1.62385700361588 bayes_pls_golite062009
protein binding 1.42349040268084 bayes_pls_golite062009
1.38236406424542 bayes_pls_golite062009
N-acetyltransferase activity 1.19037129579681 bayes_pls_golite062009
N-acyltransferase activity 0.873079221910902 bayes_pls_golite062009
transcription activator activity 0.739132967687069 bayes_pls_golite062009
transcription repressor activity 0.507152521861549 bayes_pls_golite062009
histone methyltransferase activity 0.476506467104495 bayes_pls_golite062009
protein kinase activity 0.405766438875014 bayes_pls_golite062009
acetyltransferase activity 0.39905022319963 bayes_pls_golite062009
chromatin binding 0.39425178848458 bayes_pls_golite062009
cytoskeletal protein binding 0.327424740985033 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.199823005659601 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.14235705491362 bayes_pls_golite062009
kinase activity 0.12732151557306 bayes_pls_golite062009
0.0927457062201698 bayes_pls_golite062009
sequence-specific DNA binding 0.0725773086825168 bayes_pls_golite062009
transcription factor binding 0.0538806851320555 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 0.0490968711985191 bayes_pls_golite062009
histone acetyl-lysine binding 0.0410393640547611 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQRGRGAKQS KYLGNGKPIE ASQTEESSST PPSPATKKSS KQRLTMNSRD AALDYEEYLA  60
   61 IAKEKSLIPR RSRGRTSSKS LSPPAPQDES QGTEINLKQK IE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [210-424]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EENDEILEDS KESKDENEEN KETSTTNVAE TDAPEEETVD TVEEIADEEK HSVKEESGEA  60
   61 SPQSSQQSTI TSISTTTRST RKAKREAAAE DKADLPAAVA PKPSKTRKVG GRRGKSSSND 120
  121 NHRIPQLHPD GTFVETITKP KGLHSRITMT EMRRRVASML EYIGHIQVEM AAQSAGNQSS 180
  181 TKSSKEGPEE EKETLRMVDN LTRDLLHWEQ RFSRT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle