YRC Public Data Repository - Protein Structure Prediction

Protein:	sfh1
Organism:	Schizosaccharomyces pombe
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sfh1.

Description	E-value	Query Range	Subject Range
Snr1-PA - The gene Snf5-related 1 is referred to in FlyBase by the symbol Dmel\Snr1 (CG1064, FBgn0011715). It ... gi\|220952476, gi... - gi\|220952476\|gb\|ACL88781.1\| Snr1-PA [synthetic construct], gi\|220942266\|gb\|ACL83676.1\| Snr1-PA [synt... gi\|194133435, gi... - gi\|195343661\|ref\|XP_002038414.1\| GM10810 [Drosophila sechellia], gi\|194133435\|gb\|EDW54951.1\| GM10810... gi\|194198147, gi... - gi\|195568432\|ref\|XP_002102220.1\| GD19788 [Drosophila simulans], gi\|194198147\|gb\|EDX11723.1\| GD19788 ...	312.0	[0..58]	[326..100]
SNF5_XENLA - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xen...	310.0	[0..72]	[326..129]
gi\|55742436 - ref\|NP_001006819.1\| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subf... SNF5_XENTR - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xen...	310.0	[0..72]	[326..129]
gi\|73995713 - gi\|73995713\|ref\|XP_857391.1\| PREDICTED: similar to SWI/SNF related, matrix associated, actin depende...	309.0	[0..72]	[326..137]
SNF5_BOVIN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Bos...	308.0	[0..72]	[326..136]
gi\|31338810, gi\|... - gi\|55956801\|ref\|NP_001007469.1\| SWI/SNF related, matrix associated, actin dependent regulator of chr... gi\|88758654 - gi\|88758654\|gb\|AAI13346.1\| SMARCB1 protein [Bos taurus] gi\|73995703 - gi\|73995703\|ref\|XP_543533.2\| PREDICTED: similar to SWI/SNF related, matrix associated, actin depende... gi\|114685374 - gi\|114685374\|ref\|XP_515023.2\| PREDICTED: SWI/SNF related, matrix associated, actin dependent regulat... gi\|71043654, gi\|... - gi\|71043654\|ref\|NP_001020899.1\| SWI/SNF related, matrix associated, actin dependent regulator of chr... gi\|76779705 - gi\|76779705\|gb\|AAI06700.1\| Unknown (protein for MGC:132387) [Xenopus laevis] gi\|109094828 - gi\|109094828\|ref\|XP_001084618.1\| PREDICTED: similar to SWI/SNF related, matrix associated, actin dep... gi\|148699926, gi... - gi\|74213848\|dbj\|BAE29357.1\| unnamed protein product [Mus musculus], gi\|74211546\|dbj\|BAE26504.1\| unna... gi\|194043356 - gi\|194043356\|ref\|XP_001929473.1\| PREDICTED: SWI/SNF related, matrix associated, actin dependent regu... tr\|M3W1I0\|M3W1I0... - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 OS...	308.0	[0..72]	[326..127]
gi\|114685376 - gi\|114685376\|ref\|XP_001169712.1\| PREDICTED: SWI/SNF related, matrix associated, actin dependent regu... gi\|109452096, gi... - gi\|208965588\|dbj\|BAG72808.1\| SWI/SNF related, matrix associated, actin dependent regulator of chroma... gi\|109094830 - gi\|109094830\|ref\|XP_001084732.1\| PREDICTED: similar to SWI/SNF related, matrix associated, actin dep... SMARCB1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 SNF5_MOUSE - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Mus... gi\|73995701 - gi\|73995701\|ref\|XP_848814.1\| PREDICTED: similar to SWI/SNF related, matrix associated, actin depende... HGNC:11103\|MIM:6... - related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 gi\|149043719 - gi\|149043719\|gb\|EDL97170.1\| SWI/SNF related, matrix associated, actin dependent regulator of chromat... ENSCJAT00000021013 - null gi\|194043360 - gi\|194043360\|ref\|XP_001929472.1\| PREDICTED: SWI/SNF related, matrix associated, actin dependent regu... CCDS13817.1_1 - null	307.0	[0..72]	[326..136]
gi\|182888778, gi... - gi\|54262109\|ref\|NP_571523.1\| SWI/SNF related, matrix associated, actin dependent regulator of chroma...	306.0	[0..72]	[326..117]

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Predicted Domain #1

Region A:
Residues: [1-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQACKTTYS SRLKTGNTCL IQKNVAVSTR SHSSYTGRNS LRNVPAVNYA AFEQGEDFET  60
   61 PVETPEKEEE KFETDDRGLA VGRPTGNNIY PRFATKTRHI YVTDEQLKCA AEERDVYIPI 120
  121 RLDIELPNNY RLKDTFLWNM NEQVMTPDVF AQILCADLDL STNVYGTQIS SSIRAQIEEY 180
  181 APVAEVPMPK GQEMLVVFNI QVQLAQLSYN DQVEWNLTSP LTPEEFSVLT CNDLGLSGES 240
  241 RPEIAYAIHE CLLKLKKNAC E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [262-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDLPDYDSDA VPGTKAGPRQ DMDTLGALWQ PVLETVSLED AKKNENNREN LVKQWRREAS  60
   61 KFGGFAADVS A

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [333-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERWRAAALGN LSQSETANLP SASVSDAQTL LEQERPRWRC RWCNVLGTGT FCVRRGPEGN  60
   61 KSLCNACGVA YAKTGQLPYW RKSLYT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	4gatA
Description:	Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
binding	3.48726415487797	bayes_pls_golite062009
DNA binding	3.36252792779457	bayes_pls_golite062009
nucleic acid binding	3.05528938535257	bayes_pls_golite062009
transcription factor activity	2.70303114587416	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.55186574506963	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.40923942043513	bayes_pls_golite062009
transcription activator activity	1.62405765585032	bayes_pls_golite062009
protein binding	1.60194768638501	bayes_pls_golite062009
sequence-specific DNA binding	1.5397618957429	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.37025623768659	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.26452462867497	bayes_pls_golite062009
structural constituent of ribosome	1.14370842685155	bayes_pls_golite062009
structural molecule activity	1.03433454627943	bayes_pls_golite062009
transcription coactivator activity	0.61572149323953	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
cytoskeletal protein binding	0.405267736307896	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: