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View Structure Prediction Details

Protein: iki3
Organism: Schizosaccharomyces pombe
Length: 1253 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for iki3.

Description E-value Query
Range
Subject
Range
ELP1_MOUSE - Elongator complex protein 1 OS=Mus musculus GN=Ikbkap PE=1 SV=2
983.0 [0..1] [1223..1]
ELP1_RAT - Elongator complex protein 1 OS=Rattus norvegicus GN=Ikbkap PE=2 SV=1
969.0 [0..1] [1220..1]
gi|42548196, gi|... - gi|46117038|ref|XP_384537.1| hypothetical protein FG04361.1 [Gibberella zeae PH-1], gi|42548196|gb|E...
967.0 [0..1] [1235..1]
gi|114626066, gi... - gi|114626068|ref|XP_001143066.1| PREDICTED: inhibitor of kappa light polypeptide gene enhancer in B-...
950.0 [0..1] [1222..1]
gi|12002688 - gi|12002688|gb|AAG43369.1|AF153419_1 IkappaBkinase complex-associated protein [Homo sapiens]
947.0 [0..1] [1222..1]

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Predicted Domain #1
Region A:
Residues: [1-621]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNLVTHLHH VFPNVNGSIK ALAFNSISDK IYVVCGLDNE NPGIEIYEIS ENDDVSKLVE  60
   61 FDSPSFVSDN GDIDEIQSMQ FLGEPMAICL SLKGGDIVMV KVDPSPEEAP WEIIGNVENG 120
  121 IVASCWSTDE QVFCIITGGD TILFMTKNFD IISETSLSDA DLNEFNKHIS VGWGRSETQF 180
  181 RGKRVRAKLR DPTLPEKIDE GKLSDVDDGK TYICWRGDSQ YVSINRLEKG PRRAIRVYSR 240
  241 EGLLDSISEP QDGQQSLLSW KPSGSVLATI KSDSSDNSSK VIFFERNGLR HGEFSLRRRE 300
  301 DEKYTGLAWN VSSSILAVST ENSVMLWTTG NYHWYLKKEI NIPQNALISW HPEHANTLYI 360
  361 TGKNHIEKVV FDLKYVTEFS TSPNDFGLIP VIDGSSLLVT PLSLCNIPPP MCRYKLSLDY 420
  421 NVQMTSINAT SDMLFAADDR RLTAFTFNSQ EDIAKFGEFD ISTYAEGLNF KSLLGLSGNQ 480
  481 VLLLADGTNN CSKFFVFQCD EDNESLKLLA SESFESCILN ASYCSEMLFF QTSSGKLISY 540
  541 NLNVKSIESI SLSFPKPCSD FVVVPVHETF VPIGLTSYGR LYAEQRLLST GVLSFFCTER 600
  601 FVLFTTTKNL LKFVHLVSTV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1pguA
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
snoRNA binding 3.21038659166441 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.99343906593123 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
2.40807791198019 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.5281054405163 bayes_pls_golite062009
kinase activity 1.5053563627859 bayes_pls_golite062009
RNA binding 1.50295916950465 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.33036729957356 bayes_pls_golite062009
protein kinase activity 1.3214585007945 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
ligase activity 0.93058496790047 bayes_pls_golite062009
transferase activity 0.913674310517261 bayes_pls_golite062009
cytoskeletal protein binding 0.722742354759599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription repressor activity 0.658573452658359 bayes_pls_golite062009
protein serine/threonine kinase activity 0.618638900707402 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
transcription initiation factor activity 0.262596110845942 bayes_pls_golite062009
structural molecule activity 0.254012051644049 bayes_pls_golite062009
transcription corepressor activity 0.182612389752591 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
actin binding 0.00606924241186668 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [622-755]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLQVVEDDAV DRHDERCRVV ERGSKIVASM PSKMAVVLQM PRGNLETIYP RIMVLDGVRT  60
   61 YIKALKYGDA FKVCRTHRLD LNILFDYDPD LFLKNIPVFV DGLYRVDYLD LFLTSLKPEN 120
  121 VTTGMYSDTS KSQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 2gbcA
Description: No description for 2gbcA was found.

Predicted Domain #3
Region A:
Residues: [756-857]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQSVTTIDNK VNLLCKIIRE HLTSKYGDTH FQAIITSYLC ESPPKIEAAL GMISGLIKAQ  60
   61 SETVDLAIEH MCFLVDVNML FDHALGLYDL KLALLIAQQS QK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [858-1028]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPREYVPFLH EFQKQESLRR KFNIDCYLKR YERALGHLKE MENAFDEFKN FTIQHKLYPR  60
   61 ALELYKYDKE AQKEVLIIFA QYLRENGKSN EAAIAYESVG KISEAIEAYK SAGMWRECLS 120
  121 ILQQTTNSED LIRETAEDLA SLCIEKREHC DAGSINLLYL SNPREAVIQM C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.154902
Match: 2fo7A
Description: Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1029-1098]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSQYSEAIR IARATGDSSI YKDLLISVLG ESFGEASELV ADFRNQIKSQ TERILVLREK  60
   61 KKEDPISWME 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1099-1253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTMEDQTPDD ISLASTSLST NRSLYTQYTK SSNSSKMTRN TSKNNRRLER KRARGKKGTV  60
   61 FEEEYLVNSL RRLIARVEEI RPEVHRLLEA LVRCNMTTQA SELQRNFANV IGTIGEKVIP 120
  121 ILSVPVSTFE TALGEQPQAP VVPNVKPFEK LSILI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle