YRC Public Data Repository - Protein Structure Prediction

Protein:	urg1
Organism:	Schizosaccharomyces pombe
Length:	439 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for urg1.

Description	E-value	Query Range	Subject Range
gi\|39996790, gi\|... - gi\|39996790\|ref\|NP_952741.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II [Ge...	511.0	[0..28]	[424..1]
gi\|78222835, gi\|... - gi\|78222835\|ref\|YP_384582.1\| GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase [...	511.0	[0..31]	[424..4]
gi\|125972630, gi... - gi\|67874098\|ref\|ZP_00504003.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [... gi\|196199353, gi... - gi\|196251390\|ref\|ZP_03150060.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase [Clostridium thermocel...	507.0	[0..30]	[430..3]
gi\|110547132, gi... - gi\|222055766\|ref\|YP_002538128.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase [Geobacter sp. FRC-32...	507.0	[0..33]	[424..6]
RIBAB_AQUAE, RIB... - Riboflavin biosynthesis protein ribBA OS=Aquifex aeolicus GN=ribBA PE=3 SV=1, Riboflavin biosynthesi... RIBBA_AQUAE - Riboflavin biosynthesis protein RibBA OS=Aquifex aeolicus (strain VF5) GN=ribBA PE=3 SV=1	506.0	[0..30]	[422..9]
gi\|53735199, gi\|... - gi\|67922265\|ref\|ZP_00515778.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	506.0	[0..30]	[426..11]
gi\|56750133, gi\|... - gi\|56750133\|ref\|YP_170834.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	506.0	[0..30]	[426..9]
gi\|220931844, gi... - gi\|89210620\|ref\|ZP_01189007.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	505.0	[0..31]	[430..2]
gi\|28202834, gi\|... - gi\|28210397\|ref\|NP_781341.1\| riboflavin biosynthesis protein ribA [Clostridium tetani E88], gi\|28202...	505.0	[0..30]	[424..7]
gi\|17132669, gi\|... - gi\|17231028\|ref\|NP_487576.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd... gi\|25290330 - pir\|\|AI2247 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase [imported] - Nosto...	505.0	[0..4]	[422..7]

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Predicted Domain #1

Region A:
Residues: [1-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLATEQSRPA ECNGAHAHEK TEEVKKPLYS RPVVLTTYPS QSRIDPFPMN WGAATAEERG  60
   61 PITVARSIET LPHRNAVGAH GGSYSVYNAL AVAGGFLPPD HRPNFELTEP TFDFPELDSW 120
  121 HDPKKIVAMD PYGHLTPSVF KKYLDEGYDV RPTIAITRAH LQVTEIQRSV ENGSLPIDGK 180
  181 IVLNEKGDIA VTKVAVEPVW YLPGVAERFG V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.522879
Match:	1iezA
Description:	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.265221777506021	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [212-439]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEVTLRRALF EQMGGAYPEL ITRPDIKVFL PPIGGLTAYI FGPPEYLSDT SKSLAVRVHD  60
   61 ECNGSDVFQS DICTCRPYLT FGIEEAAKEA QNGGAGLVVY FRKEGRALGE VVKYLVYNKR 120
  121 KRTGDSAENY FKRTEELAGV RDMRFQALMP DILHWFGIKK IDRMLSMSNM KHDAIVGQGI 180
  181 KILNRITIPD DLIPEDSQVE IDAKIQSGYF SEKKVTEDDL SCVHGRHW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.30103
Match:	2bz0A
Description:	Crystal Structure of E. coli GTP cyclohydrolase II in complex with GTP analogue, GMPcPP, and Zinc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.641212200472049	bayes_pls_golite062009
binding	0.541272319408336	bayes_pls_golite062009
hydrolase activity	0.282917045029035	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: