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View Structure Prediction Details

Protein: thi5
Organism: Schizosaccharomyces pombe
Length: 857 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for thi5.

Description E-value Query
Range
Subject
Range
gi|49644424|emb|... - unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
gi|49644424, gi|... - gi|50310537|ref|XP_455288.1| unnamed protein product [Kluyveromyces lactis], gi|49644424|emb|CAG9799...
235.0 [0..30] [857..6]
SPAC3C7.04 - transcription factor
YF54_SCHPO - Uncharacterized transcriptional regulatory protein C3C7.04 OS=Schizosaccharomyces pombe (strain 972 ...
219.0 [0..299] [856..225]
gi|49066876, gi|... - gi|71003159|ref|XP_756260.1| hypothetical protein UM00113.1 [Ustilago maydis 521], ref|XP_397728.1| ...
216.0 [0..3] [854..45]
gi|32413891, gi|... - gi|32413891|ref|XP_327425.1| hypothetical protein [Neurospora crassa], gi|28921809|gb|EAA31086.1| hy...
gi|85096757 - gi|85096757|ref|XP_960322.1| hypothetical protein [Neurospora crassa OR74A]
214.0 [0..1] [799..1]
gi|67536776, gi|... - gi|67536776|ref|XP_662162.1| hypothetical protein AN4558.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
213.0 [0..218] [857..154]
gi|38566844 - gi|38566844|emb|CAE76150.1| related to transcriptional activator Mut3p [Neurospora crassa]
213.0 [0..26] [846..57]
gi|499202 - gi|499202|gb|AAA19010.1| transcription factor [Schizosaccharomyces pombe]
208.0 [0..297] [827..208]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCPSDFSSRS LFLEAKEEEY KQRRRVPLDS RRRVRRACLS CRAKKIRCSG SEPCQACIAT  60
   61 PSQCKYADSL KERTPSKQFI AELSQRQKCF EYLMELL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 1zmeC
Description: PUT3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [98-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPSLPHDTRS LVKLCKHVES SLASGSDVRS LLIPGSIDQS VLKVAATNNK DDSSAVKSAN  60
   61 VSFPSSSTPP SSDSNFSSIQ NTDLNTSIKF TENISANAIH VNQDKVIRSA NNLIINSQPI 120
  121 LPVRSFLDAL GEPIYLSPTS STYFLNSVLA SLQLNSSNT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.32
Match: 1pyiA
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 4.03985756894684 bayes_pls_golite062009
nucleic acid binding 3.97978190843512 bayes_pls_golite062009
transcription factor activity 2.87348461329489 bayes_pls_golite062009
binding 2.82809978070212 bayes_pls_golite062009
sequence-specific DNA binding 2.77469997789536 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.70904317608141 bayes_pls_golite062009
transcription activator activity 2.1512787242583 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.08956709478484 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [257-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESLLIDYQS KIPEDLSSSL LPLELNTLQS TPTSVSVGSA SSQGTHEYSI INLTSNHSSF  60
   61 SLKALKKIAH NLLPPVSVAE RYANEFFLRY QSF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.823 0.021 thiamin biosynthetic process a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain

Predicted Domain #4
Region A:
Residues: [350-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FYFYPPSVFS NRYQILADGL VNSDTLDTGF LAVALLIVVL GHFSNNNINV LPKEVQLSHI  60
   61 DSMIQISEQL ISSLLNRCTL SSIQAVFLLS LYHFLTGNFK CAYSYLGFAI HSAHTLGLEH 120
  121 GSTDNSTLNE VSTEETSIRI CWSLRVLASF LYIQSGITPI INLFPNGLNS LKL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 19.0
Match: PF04082.9
Description: No description for PF04082.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [523-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTVVPELEAR HLPSSVFHFV AIIKYAEISV RSLNSLYESS SDYLMDVSNF PKLLLKVERI  60
   61 YSQARNWKLN LTHQQLNGTN DTSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [607-857]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLFHSNVSLH LFYHYLIVKV SCPIMFFYLN NWYSVKPSSF TKGLNNKPSL EDVFSNLETC  60
   61 YESAKAIVQL SSKLLSAGQM DKCFYLEFEI LYCSAIVLFL FSVMHLGAEN PLLESIYLLE 120
  121 DMGSRTIDSK VRLEKLKSAI EIFDINSATE MPINEPLSAS FESVNKENSQ SGYMAWQNWV 180
  181 TELSSSNIPL GHALGNPESN NSSNSFKPSH PSQSFLVNES LDFSSNPKEP PFLPWSEALL 240
  241 NMDMQLNRLG P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle