YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC1734.11
Organism:	Schizosaccharomyces pombe
Length:	407 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1734.11.

Description	E-value	Query Range	Subject Range
gi\|53134035, gi\|... - gi\|57524857\|ref\|NP_001005841.1\| DnaJ (Hsp40) homolog, subfamily A, member 2 [Gallus gallus], gi\|5313...	369.0	[0..2]	[407..4]
gi\|47220868 - gi\|47220868\|emb\|CAG03075.1\| unnamed protein product [Tetraodon nigroviridis]	365.0	[0..2]	[406..5]
gi\|114624360 - gi\|114624360\|ref\|XP_001154348.1\| PREDICTED: similar to DnaJ-like protein [Pan troglodytes]	365.0	[0..1]	[406..100]
gi\|49527454 - gi\|49527454\|emb\|CAG61094.1\| unnamed protein product [Candida glabrata] gi\|50291421, gi\|... - gi\|50291421\|ref\|XP_448143.1\| unnamed protein product [Candida glabrata], gi\|49527454\|emb\|CAG61094.1\|...	365.0	[0..1]	[407..1]
YDJ1 - Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein trans... MAS5_YEAST - Mitochondrial protein import protein MAS5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	363.0	[0..1]	[407..1]
gi\|32880141, gi\|... - gi\|61371402\|gb\|AAX43661.1\| DnaJ-like subfamily A member 1 [synthetic construct], gi\|32880141\|gb\|AAP8...	362.0	[0..1]	[406..1]
gi\|34013390 - gi\|34013390\|dbj\|BAC82111.1\| DnaJ (Hsp40) homolog, subfamily A, member 1 [Cricetulus griseus] DNJA1_MOUSE - DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 DNJA1_RAT - DnaJ homolog subfamily A member 1 OS=Rattus norvegicus GN=Dnaja1 PE=1 SV=1	361.0	[0..1]	[406..1]
gi\|32450159, gi\|... - gi\|32450159\|gb\|AAH53791.1\| Dnaja2-prov protein [Xenopus laevis], gi\|148227640\|ref\|NP_001080625.1\| Dn...	361.0	[0..2]	[407..4]
gi\|57093651, gi\|... - gi\|73979910\|ref\|XP_849937.1\| PREDICTED: similar to DnaJ homolog subfamily A member 1 (Heat shock 40 ... CCDS6533.1_1 - null gi\|109111254, gi... - gi\|109111254\|ref\|XP_001102042.1\| PREDICTED: DnaJ (Hsp40) homolog, subfamily A, member 1 isoform 4 [M... ENSOCUP000000041... - pep:novel chromosome:oryCun2:1:20384826:20394454:-1 gene:ENSOCUG00000004833 transcript:ENSOCUT000000... gi\|123980376, gi... - gi\|60654863\|gb\|AAX31996.1\| DnaJ-like subfamily A member 1 [synthetic construct], gi\|60654861\|gb\|AAX3... tr\|M3WA49\|M3WA49... - DnaJ heat shock protein family (Hsp40) member A1 OS=Felis catus GN=DNAJA1 PE=3 SV=1 gi\|149725925, gi... - gi\|149736914\|ref\|XP_001499107.1\| PREDICTED: similar to DnaJ homolog subfamily A member 1 (Heat shock... DNAJA1 - DnaJ (Hsp40) homolog, subfamily A, member 1 ENSPTRT00000038574 - null ENSCJAT00000015678 - null	360.0	[0..1]	[406..1]
DNJA1_BOVIN - DnaJ homolog subfamily A member 1 OS=Bos taurus GN=DNAJA1 PE=2 SV=2	360.0	[0..1]	[406..1]

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Predicted Domain #1

Region A:
Residues: [1-107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKETKLYEV LNVDVTASQA ELKKAYRKLA LKYHPDKNPN AGDKFKEISR AYEILADEEK  60
   61 RATYDRFGEE GLQGGGADGG MSADDLFASF FGGGMFGGGM PRGPRKG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.30103
Match:	1xblA
Description:	NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	3.04403163860617	bayes_pls_golite062009
chaperone binding	2.86745334638583	bayes_pls_golite062009
protein binding	2.65982681685488	bayes_pls_golite062009
binding	2.63138872417193	bayes_pls_golite062009
heat shock protein binding	2.17994194200939	bayes_pls_golite062009
transcription regulator activity	1.91297632253219	bayes_pls_golite062009
nucleic acid binding	1.6342534817623	bayes_pls_golite062009
DNA binding	1.55234338199368	bayes_pls_golite062009
transporter activity	1.29863098651348	bayes_pls_golite062009
substrate-specific transporter activity	0.812144232432417	bayes_pls_golite062009
protein transporter activity	0.599800483479766	bayes_pls_golite062009
Hsp70 protein binding	0.541755903922701	bayes_pls_golite062009
transferase activity	0.240656521918556	bayes_pls_golite062009
catalytic activity	0.106988907594358	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0276971914937192	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [108-407]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLVHTIKVT LEDLYRGKTT KLALQKKVIC PKCSGRGGKE GSVKSCASCN GSGVKFITRA  60
   61 MGPMIQRMQM TCPDCNGAGE TIRDEDRCKE CDGAKVISQR KILTVHVEKG MHNGQKIVFK 120
  121 EEGEQAPGII PGDVIFVIDQ KEHPRFKRSG DHLFYEAHVD LLTALAGGQI VVEHLDDRWL 180
  181 TIPIIPGECI RPNELKVLPG QGMLSQRHHQ PGNLYIRFHV DFPEPNFATP EQLALLEKAL 240
  241 PPRKIESAPK NAHTEECVLA TVDPTEKVRI DNNVDPTTAT SMDEDEDEEG GHPGVQCAQQ 300
  301

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.221849
Match:	1nltA
Description:	The crystal structure of Hsp40 Ydj1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.7298921704023	bayes_pls_golite062009
protein binding	2.6297172985864	bayes_pls_golite062009
protein disulfide isomerase activity	2.4409950647303	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.4409950647303	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.23398279564144	bayes_pls_golite062009
unfolded protein binding	2.04158808514315	bayes_pls_golite062009
receptor binding	0.395342079633271	bayes_pls_golite062009
catalytic activity	0.276917867171685	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: